September 5, 2018

Fred Prior, Ph.D.

Cancer Institute Member Spotlight
Professor and Chair

Department of Biomedical Informatics

Research Interest Statement

My research focuses on imaging informatics and quantitative image analysis. I have spent most of my career designing health care and, more recently, research information management systems to include NCI’s Cancer Imaging Archive (TCIA). TCIA provides open access data, is built on open source software and supports open science, all areas of interest and focus for my research. We have used TCIA as a research platform to explore advanced issues in data acquisition, management, analysis and information fusion. I have spent the last 15 years focused on advancing the science of quantitative image analysis to extract new and more reliable information from medical images and electromagnetic signals, primarily in cancer but also in pursuit of understanding the functioning of the brain in both health and disease.  Currently, I am working on both lung cancer radiomics and trying to develop a new program in neuroimaging informatics drawing heavily on my experience as a member of the Human Connectome project team.

Peer-Reviewed Grants

NCI – 5 U24 CA215109-02  
TCIA Sustainment and Scalability – Platforms for Quantitative Imaging Informatics in Precision Medicine
09/22/2017 – 07/312022
$1,490,178*

NCI – 5 U54 CA199092-04
Cancer Center of Nanotechnology Excellence
10/01/2015 – 07/31/2020
$27,728*

PCORI – PCS-14-03-12804                                             
Pragmatic Randomized Trial of Proton vs. Photon Therapy for Patients with Non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness Trial (RADCOMP)
11/01/2015 – 10/31/2020
$95,561*

NCI – HHSN261200800001E
TCIA RFP S16-011 (#2)
09/29/2015 – 09/25/2018
$595,470*

NCI – HHSN261200800001E                                          
TCIA RFP S16-011 (#3)
09/29/2015 – 09/25/2018
$163,790*

NCI – HHSN261200800001E                                          
TCIA RFP S16-011 (#5)
12/15/2016 – 09/25/2018
$5,645*

NCI – 5 U01 CA187013-05                                              
Resources for Development and Validation of Radiomic Analyses & Adaptive Therapy
09/01/2014 – 08/31/2019
$323,235*

* cancer-related annual direct costs

Dr. Prior’s UAMS Collaborators

Lawrence Tarbox

Mathias Brochhausen

Jonathan Bona

Yasir Rahmatallah

Ahmad Baghal

Melody Penning

Bill Bennett

Kirk Smith

Tracy Nolan

Linda Larson-Prior

Jeanne Wei

Jeannette Lee

Laura James

Kristie Hadden

Dr. Prior’s External Collaborators

Xiuzhen Huang – Arkansas State University

Jason Causey– Arkansas State University

Ashish Sharma – Emory University

Andrew Post – Emory University

Walter Bosch – Washington University in St. Louis

Malcolm Tobias – Washington University in St. Louis

Sam Achilefu – Washington University in St. Louis

David Sinacore – Washington University in St. Louis

Paul Commean – Washington University in St. Louis

David Politte – Washington University in St. Louis

Stephen Moore – Washington University in St. Louis

Joel Saltz – Stony Brook University

Tahsin Kurc – Stony Brook University

Justin Bekelman – University of Pennsylvania

Mike Becich – University of Pittsburgh

TJ Fitzgerald – University of Massachusetts

Andrey Federov – Harvard University

Jayashree Kalpathy-Cramer – Harvard University

John Freymann – NCI Frederick National Laboratory

Justin Kirby – NCI Frederick National Laboratory

You might not know that …

My wife and I are passionate about ballroom dancing and travel to competitions across the country. I enjoy golf, even though it is not my strong suit, and fly fishing.  We both enjoy hiking and would love to get our kayaks back into the water, even though they are designed for the ocean and have been in both the Pacific and Atlantic.

Recent Cancer Related Publications:

Causey JL, Zhang J, Ma S, Jiang B, Qualls JA, Politte DG, Prior F, Zhang S, Huang X. Highly accurate model for prediction of lung nodule malignancy with CT scans. Sci Rep. 2018 Jun 18;8(1):9286.  PMID: 29915334  PMCID: PMC6006355

Prior F, Smith K, Sharma A, Kirby J, Tarbox L, Clark K, Bennett W, Nolan T, Freymann J. The public cancer radiology imaging collections of The Cancer Imaging Archive. Sci Data. 2017 Sep 19;4:170124. PMID: 28925987 PMCID: PMC5827108

Benedict SH, Hoffman K, Martel MK, Abernethy AP, Asher AL, Capala J, Chen RC, Chera B, Couch J, Deye J, Efstathiou JA, Ford E, Fraass BA, Gabriel PE, Huser V, Kavanagh BD, Khuntia D, Marks LB, Mayo C, McNutt T, Miller RS, Moore KL, Prior F, Roelofs E, Rosenstein BS, Sloan J, Theriault A, Vikram B. Overview of the American Society for Radiation Oncology-National Institutes of Health-American Association of Physicists in Medicine Workshop 2015: Exploring Opportunities for Radiation Oncology in the Era of Big Data. Int J Radiat Oncol Biol Phys. 2016 Jul 1;95(3):873-879. PMID: 27302503  PMCID: PMC4965164

McCann SM, Jiang Y, Fan X, Wang J, Antic T, Prior F, VanderWeele D, Oto A. Quantitative Multiparametric MRI Features and PTEN Expression of Peripheral Zone Prostate Cancer: A Pilot Study. AJR Am J Roentgenol. 2016 Mar;206(3):559-65.  PMID: 26901012

Rosenstein BS, Capala J, Efstathiou JA, Hammerbacher J, Kerns SL, Kong FS, Ostrer H, Prior FW, Vikram B, Wong J, Xiao Y. How Will Big Data Improve Clinical and Basic Research in Radiation Therapy? Int J Radiat Oncol Biol Phys. 2016 Jul 1;95(3):895-904. Epub 2015 Nov 11. PMID: 26797542  PMCID: PMC4864183