March 1, 2019

Marie Burdine, Ph.D.

Assistant Professor
Department of Surgery, Division of Surgical Research
Department of Biochemistry and Molecular Biology (secondary appointment)
UAMS College of Medicine

Research Statement

Gastrointestinal cancers are particularly difficult to treat with reoccurrence and chemoresistance prevalent. It is the mission of the Burdine laboratory to work with surgical oncologists across UAMS campus to analyze the epigenetic profiles of gastrointestinal cancers in order to provide insight into the molecular mechanisms that drive gastrointestinal cancer progression and chemoresistance.

In addition, our laboratory focuses on the prevention of post-transplant lymphoproliferative disorder (PTLD), a type of lymphoma resulting from uncontrolled B cell proliferation and an unfortunate side effect of chronic immunosuppression in solid organ and hematopoietic stem cell transplant patients. We are investigating a novel form of immunosuppression that inhibits the proliferation of B cells and the production of donor-specific antibodies that contribute to antibody-mediated organ rejection. In vivo models of EBV-associated PTLD are used in the lab to determine the effectiveness of this immunosuppression therapy in PTLD prevention.

Dr. Burdine’s Grants

Winthrop P. Rockefeller Cancer Institute Foundation Envoys

Seeds of Science

$10,000*

2/2018-2/2019

A Novel Mechanism for Regulating the Oncogenic Activity of ATAD2

 

Marion B. Lyon New Scientist Development Award

$13,041*

5/2018 – 5/2020

Inhibition of DNA-PK(cs) as Novel Immunosuppression Therapy for Pediatric Transplant Patients

* cancer-related annual direct costs

 

UAMS Collaborators

Kevin Sexton, M.D. (Surgery)

Lyle Burdine, M.D., Ph.D. (Surgery)

Camilo Barreto, M.D. (Surgery)

Jill Mhyre, M.D. (Anesthesiology)

Nadir El Sharawi, M.D. (Anesthesiology)

Sara Shalin, M.D., Ph.D. (Dermatology, Pathology)

Felicia Allard, M.D. (Pathology)

Eric Yee, M.D. (Pathology)

Stephanie Byrum, Ph.D. (Bioinformatics Core)

 

External Collaborators

Michael Schulz, Ph.D. (Virginia Tech, Chemistry)

Brady Hall, Ph.D. (Virginia Tech, Chemistry)

Jay Chung, Ph.D. (NIH/NHLBI)

Anthony Davis, Ph.D. (UT Southwestern, Radiation Oncology)

 

Opportunities for Collaborations

I welcome collaborations with any scientist or clinician who is interested in analysis of human tumor samples for identifying novel therapeutic approaches. As part of the Division of Surgical Research, I would like to encourage any clinician with basic science ideas or novel procedural techniques to contact me to help get your project up and running.

You Might Not Know That …

I enjoy listening to 1310 The Ticket for sports news, as well as hiking, fishing and a building a campfire on a cool night!

Cancer-Related Publications

Schluterman, Burdine MK, Chapman SL, Korpanty G, Ozumi K, Fukai T, Yanagisawa H and Brekken RA. Loss of endogenous fibulin-5 inhibits pancreatic tumor growth by increasing the level of ROS in the tumor microenvironment. Dis Model Mech. 2010 May-Jun;3(5-6):333-42.

Burdine, L, Burdine MS, Moreland L, Fogel B, Orr LM, James J, Turnage RH, Tackett AJ. Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway. PLoS One. 2015 June 11;10(6)e0127943.

Kim Wiese A, Schluterman Burdine M, Turnage RH, Tackett AJ, Burdine LJ. DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes. PLoS One. 2017 Jul 27;12(7):e0181608.