September 11, 2019

Darin Jones, Ph.D.

Associate Professor of Pharmaceutical Sciences
UAMS College of Pharmacy

Research Interest Statement

My research interests are broadly in the area of medicinal chemistry and chemical biology. Specifically we study essential proteins involved in DNA damage response and repair processes (DDR). Using fragment-based screening and computer-aided drug design techniques, we develop small molecule inhibitors and chemical tool compounds of these essential proteins to provide a greater understanding of the mechanisms of DDR and of chemotherapeutic drug resistance.

Dr. Jones’ Grants

NIH/Nat. Inst. of General Medical Sciences 

Sub-award from University of New Mexico

Jones, Darin: PI

Title “Cellular Functions of Eukaryotic DNA Ligases”

08/01/2018 to 07/31/2022

$130,068*

*cancer-related direct costs

 

NIH/NCI 

Sub-award from UT Health Science Center at Houston

Jones, Darin: PI

Title “Pharmacological Modulation of Poly (ADP-ribose) Metabolism”

09/01/2018 to 02/28/2021

$256,701*

*cancer-related direct costs

 

NIH/NCI 

Sub-award from University of California, Berkeley

Jones, Darin: PI

Title “Structural Cell Biology of DNA Repair Machines”

09/01/2018 to 08/31/2021

$100,191*

*cancer-related direct costs

Dr. Jones’ UAMS Collaborators

Cesar M. Compadre, B.S.Pharm., M.S., Ph.D., Professor of Pharmaceutical Sciences

Dr. Jones’ External Collaborators

Zamal Ahmed, Ph.D., University of Texas MD Anderson Cancer Center

John A. Tainer, Ph.D., University of Texas MD Anderson Cancer Center

Alan Tomkinson, Ph.D., University of New Mexico Comprehensive Cancer Center

Anthony J. Davis, Ph.D., University of Texas Southwestern Medical Center

Opportunities for Collaboration

I am always excited about potential collaboration opportunities and contributing to important problems. I would appreciate the opportunity to discuss how we may be able to help from target identification/validation to development of novel chemical tools.

You May Not Know That …

I enjoy traveling with the family and motorcycling riding. 

Recent Cancer-Related Publications

Structure-activity Relationships among DNA Ligase Inhibitors: Characterization of a Selective Uncompetitive DNA Ligase I Inhibitor. Howes, Rimothy, R.L.; Sallymr, Annahita; Brooks, Rhys; Greco, George, E.; Jones, Darin E.; Matumoto, Yoshihiro; Tomkinson, Alan, E. DNA Repair, 2017, 60, 29-39.

Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. Ordonez, Paola E.; Sharma, Krishan K.; Bystrom, Laura M.; Alas, Maria A.; Enriquez, Raul G.; Malagon, Omar; Jones, Darin E.; Guzman, Monica L.; Compadre, Cesar M. J. Nat. Prod., 2016, 79, 691.

Structure-based Discovery of Small Molecule Hepsin and HGFA Protease Inhibitors: Evaluation of Potency and Selectivity Derived from Distinct Binding Pockets. Franco, Francisco M.; Jones, Darin E.; Harris, Peter K.W.; Han, Zhenfu; Wildman, Scott A.; Jarvis, Cassie M.; Janetka, James W. Bioorg. Med. Chem., 2015, 23, 2328.

Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer. Han, Zhenfu; Harris, Peter K.W.; Jones, Darin E.; Chugani, Ryan; Kim, Tommy; Agarwal, Manjula; Shen, Wei; Wildman, Scott A.; Janetka, James W. ACS Med. Chem. Lett., 2014, 5, 1219.