October 24, 2019

Donald J. Johann Jr., M.Sc., M.D., FACP

Associate Professor
Department of Biomedical Informatics
UAMS College of Medicine
Scientific Director, UAMS Genomics Facility

Research Interest Statement

As a medical oncologist, I focus on the application of advanced molecular profiling and high-throughput technologies for the characterization of genetic-based alterations in cancer cells. Areas of emphasis include: cancer biology and bioinformatics; Next-Gen Sequencing (NGS), high-resolution identity-based mass spectrometry (proteomics) and laser capture microdissection (LCM).

I became a physician as a second career. Prior to medical school, I worked as an engineer for the Sperry/Unisys Corp for six years. Rising through the ranks, I directed a group of five engineers on research and development projects involving systems level software (OS, compilers), avionic software and instrumentation.

Dr. Johann’s Grants

FDA/Arkansas Research Alliance Sub: HHSF2232016111C

Donald Johann Jr: Project PI

Title “Scientific and Methodological Advancement in Liquid Biopsies to Further the Development of Lung Cancer-Based precision Medicine (Bio 3)”

10/01/2016 to 09/29/2020

$839,975*

 

NIH/NCI: R33CA202811

Donald Johann Jr: Project PI

Title “Development and Validation of a Microdissection Method to Advance Precision Medicine in the Clinical Setting”

05/01/2016 to 04/30/2020

$959,495*

 

Breast Cancer Research Foundation/University of Michigan Sub: N013869 

Donald Johann Jr: Site Project PI

Title “Financial Support for the Breast Cancer Intergroup Correlative Science Studies”

10/01/2015 to 09/30/2019 (awaiting notice of extension)

$82,705*

 

FDA/Arkansas Research Alliance Sub: HHSF2232016111C

Donald Johann Jr: Project PI

Title “Scientific and Methodological Advancement in Liquid Biopsies to Further the Development of Lung Cancer-Based Precision Medicine”

10/01/2016 to 09/29/2020

$596,021*

*cancer-related direct cost

Dr. Johann’s UAMS Collaborators

Mathew Steliga, M.D., Department of Surgery, Thoracic Oncology

Jason Muesse, M.D., Department of Surgery, Thoracic Oncology

Dr. Johann’s External Collaborators

Michael Tangrea, Ph.D., LifeBridge Health

Michael Emmert-Buck, M.D., Ph.D., Avoneaux Medical Institute

Josip Blonder, M.D., Frederick National Lab for Cancer Research

Opportunities for Collaboration

My opportunities for collaboration include the areas of genomics or advanced molecular profiling for cancer and molecular medicine.

You May Not Know That …

I coach my son’s basketball team.

Recent Cancer-Related Publications

Johann DJ, Steliga M, Shin IJ, Yoon D, Jeffers S, Arnaoutakis K, Hutchins L, Liu M, Liem J, Walker K, Pereira A, Yang M, Peterson E, Xu J. Liquid Biopsy and its Role in an Advanced Clinical Trial for Lung Cancer, 2018 Experimental Biology and Medicine, 262-71.

Ye X, Luke BT, Wei BR, Kaczmarczyk JA, Loncarek J, Dwyer JE, Johann DJ, Saul RG, Nissley DV, McCormick F, Whiteley GR, Blonder J. Direct Molecular Dissection of Tumor Parenchyma from Tumor Stroma in Tumor Xenografts Using Mass Spectrometry Based Glyco-Proteomics. 2018 Oncotarget, 26431-26452.

Hipp JD, Johann DJ, Chen Y, Madabhushi A, Monaco J, Chemg J, Rodriguez-Canales J, Stumpe MC, Riedlinger G, Rosenberg AZ, Hanson JC, Kunju LP, Emmert-Buck MR, Balis UJ, Tangrea MA. Computer Aided Laser Dissection: A Microdissection Workflow Leveraging Image Analysis Tools. 2018 Journal of Pathology Informatics, 9:45, 1-9.