October 7, 2019

Marjan Boerma, Ph.D.

Associate Professor of Pharmaceutical Sciences
UAMS College of Pharmacy

Research Interest Statement

The overall objective of my research is to elucidate biological mechanisms by which ionizing radiation causes injury in normal (non-cancerous) tissues and to identify countermeasures to intervene in these injuries. Our laboratory has a particular focus on radiation injury in the cardiovascular system. We use in vivo models that address cardiac side effects of radiation therapy, whole-body radiation exposure due to radiological accidents, and cardiovascular effects of charged particle radiation to mimic exposures during travel in deep space. Our lab has long-term experience with in vivo echocardiography, ex vivo cardiac function measurements, and histological and molecular analyses of the heart.

Dr. Boerma’s Cancer-Related Grants

NIH/NIGMS: 5P20GM109005

Boerma, Marjan: Sub-Project PI

Title “Center for Studies of Host Response to Cancer Therapy-Irradiation and Animal Core”

06/24/2015 to 03/31/2020

$852,760*

NASA

Boerma, Marjan: PI

Title “Tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects”

01/31/2019 to 01/30/2021

$301,354*

*cancer-related annual direct costs

Dr. Boerma’s UAMS Collaborators

Antino Allen, Ph.D., Department of Pharmaceutical Sciences

Nukhet Aykin-Burns, Ph.D., Department of Pharmaceutical Sciences

Martin Hauer-Jensen, M.D., Ph.D., Department of Pharmaceutical Sciences

Se-Ran Jun, Ph.D., Department of Biomedical Informatics

Thomas Kim, M.D., Department of Radiation Oncology

Igor Koturbash, M.D., Ph.D., Department of Environmental and Occupational Health

Reid Landes, Ph.D., Department of Biostatistics

Chenghui Li, Ph.D., Department of Pharmacy Practice

Sanjay Maraboyina, M.D., Department of Radiation Oncology

Ganesh Narayanasamy, Ph.D., Department of Radiation Oncology

Mausam Patel, M.D., Department of Radiation Oncology

Rupak Pathak, Ph.D., Department of Pharmaceutical Sciences

Snehalata Pawar, Ph.D., Department of Pharmaceutical Sciences

Dr. Boerma’s External Collaborators

Amrita Cheema, Ph.D., Georgetown University

John Griffin, Ph.D., Scripps Research

Vivien Mao, M.D., Ph.D., Loma Linda University

Meetha Medhora, Ph.D., Medical College Wisconsin

Michael Weil, Ph.D., Colorado State University

Hartmut Weiler, Ph.D., Versiti Bloodcenter

Opportunities for Collaboration

I am happy to collaborate on studies in which my expertise in radiation biology can be of help. In addition, as the director of the Ultrasound Imaging Core and the Experimental Radiation Core at UAMS, I am happy to discuss how we can assist in your research.

You Might Not Know That …

I have been lucky to visit a total of 19 European countries and hope to grow this number in the future.

Recent Cancer-Related Publications

Vijayalakshmi Sridharan, John W. Seawright, Francis J. Antonawich, Merrill Garnett, Maohua Cao, Preeti Singh, Marjan Boerma. Late administration of a palladium lipoic acid complex (POLY-MVA) modifies cardiac mitochondria but not functional or structural manifestations of radiation-induced heart disease in a rat model. Radiation Research 2017, 187: 361-366

Chhanda Bose, Sanjay Awasthi, Rajendra Sharma, Helen Beneš, Martin Hauer-Jensen, Marjan Boerma, Sharda P. Singh. Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model. PloS One 2018; 13: e0193918

Nukhet Aykin-Burns, Rupak Pathak, Marjan Boerma, Thomas Kim, Martin Hauer-Jensen. Utilization of vitamin E analogs to protect normal tissues while enhancing anti-tumor effects. Seminars in Radiation Oncology 2019; 29: 55-61.