November 26, 2019

Rupak Pathak, Ph.D.

Assistant Professor
Division of Radiation Health
Department of Pharmaceutical Sciences
UAMS College of Pharmacy

Research Interest Statement

Dr. Pathak’s research focuses on understanding the role of stromal cells in intestinal repair following injury, specifically after radiation injury. In addition, he is interested to dissect the underlying mechanisms of immune-epithelial crosstalk in intestinal restoration following localized fractionated radiation, acute dose of total body irradiation, or low-dose and low dose-rate of chronic irradiation. The overall goal of these projects is to identify the new molecular targets, which can be used to protect the intestine from radiation damage, as well as from injuries caused by toxic chemicals, pathological conditions (including cancer), and various other tissue injuries, such as intestinal injury due to ischemia/reperfusion.

Dr. Pathak is also pursuing another project to determine the role of platelet-leukocyte interaction in modifying radiation response using various transgenic mouse models. Since platelets play a crucial role in regulating inflammation and thrombosis, two major closely interdependent pathophysiological events occur following tissue injury. The goal of this project is to lay a foundation for novel therapies, not only to restrict healthy tissue damage following irradiation, but also to reduce the risk of developing other radiation-induced inflammatory and thrombotic diseases, such as atherosclerosis, venous thromboembolism, fibrosis, cardiovascular disease and cancer.

Furthermore, Dr. Pathak is an expert in cytogenetic studies. He is investigating molecular mechanisms involved in genetic instability due to radiation damage or various pathological conditions by using cutting edge molecular cytogenetic techniques, such as mFISH and spectral karyotyping.

 

Dr. Pathak’s Cancer-related Grants

NIH/NIGMS: 5P20GM109005

Pathak, Rupak: Sub-Project PI

Title “Role of KLF2 in Regulating Intestinal Radiation Toxicity”

06/24/2015 to 03/31/2020

$180,000*

 

NIH/NCI: Univ of Florida Sub- UFDSP00012380

Rupak Pathak: Site Project PI

Title “Ionizing Radiation Induced Hematological Malignancies”

09/01/2018 to 03/31/2022

$27,460*

 

NASA/Arkansas Space Grant Consortium

Rupak Pathak: Site Project PI

Title “Studies of Endothelial Dysfunction under Simulated Space Environment”

07/01/2019 to 05/31/2020

$14,000*

*cancer-related direct cost

 

Dr. Pathak’s UAMS Collaborators

Jerry Ware, Ph.D. – Department of Physiology and Biophysics, College of Medicine

Marjan Boerma, Ph.D. – Department of Pharmaceutical Sciences, College of Pharmacy

Alexei Basnakian, Ph.D. – Department of Pharmacology and Toxicology, College of Medicine

Justin Wai Chung Leung, Ph.D. – Department of Radiation Oncology, College of Medicine

 

Dr. Pathak’s External Collaborators

Daohong Zhou, Ph.D. – Department of Pharmacodynamics, University of Florida

 

Opportunities for Collaboration

I am eager for opportunities to collaborate with colleagues at UAMS. My scientific expertise is in intestinal biology and radiation, which can be useful in identifying novel cancer biology or innovative therapies. I encourage anyone to stop by to discuss new ideas, projects or collaborations.

 

You May Not Know That …

I love any kind of sports, particularly soccer, tennis and cricket. I also enjoy listening to classical music.

 

Recent Cancer-Related Publications

Pathak R*, Bachri A, Ghosh SP, Koturbash I, Boerma M, Binz RK, Sawyer JR, Hauer-Jensen M. The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage. Pharm Res. 2016 Sep;33(9):2117-25. [PMID: 27216753]

Pathak R, Wang J, Garg S, Aykin-Burns N, Petersen KU, Hauer-Jensen M. Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model. Radiat Res. 2016 Aug;186(2):112-20. [PMID: 27459702]

Pathak R*, Ghosh SP, Zhou D, Hauer-Jensen M. The Vitamin E analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM). Int J Mol Sci. 2016 Nov 18;17(11) [PMID: 27869747]

Pathak R*, Koturbash I, Hauer-Jensen M. Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice. J Vis Exp. 2017 Jan 11; (119). [PMID: 28117817]

Pathak R*, Shah SK, Hauer-Jensen M. 2018. Therapeutic potential of natural plant products and their metabolites in preventing radiation enteropathy resulting from abdominal or pelvic irradiation. Int J Radiat Biol. 2018 Dec 7:1-43. [PMID: 30526224]

Garg S, Sadhukhan R, Banerjee S, Savenka AV, Basnakian AG, McHargue V, Wang J, Pawar SA, Ghosh SP, Ware J, Hauer-Jensen M, Pathak R*. Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery. Antioxidants (Basel). 2019 Mar 6;8(3). pii: E57. [PMID: 30845647]

Pathak R, Kumar VP, Hauer-Jensen M, Ghosh SP. Enhanced Survival in Mice Exposed to Ionizing Radiation by Combination of Gamma-Tocotrienol and Simvastatin. Mil Med. 2019 Mar 1;184(Supplement_1):644-651. [PMID: 30901461]

Binz RL, Tian E, Sadhukhan R, Zhou D, Hauer-Jensen M, Pathak R*. Identification of novel breakpoints for locus- and region-specifictranslocations in 293 cells by molecular cytogenetics before and after irradiation. Sci Rep. 2019 Jul 22;9(1):10554 [PMID: 31332273]