December 19, 2019

Charles O’Brien, Ph.D.

Department of Internal Medicine
Division of Endocrinology and Metabolism
UAMS College of Medicine
VA Research Scientist

Research Interest Statement

The focus of my research is to understand the cellular and molecular mechanisms that control bone remodeling. Alterations in bone remodeling underlie changes in the skeleton that lead to osteoporosis. As part of this effort, we generate novel genetically modified in vivo models using a variety of approaches, including transgenesis, gene targeting and gene editing. I have been continuously funded by the NIH as a principal investigator since 1998 and by the Veteran’s Administration since 2009.

Dr. O’Brien’s Cancer-related Grants

NIH/NIGMS: P20GM125503

Role: Project PI

Title “Center for Musculoskeletal Disease Research (CMDR)”

02/16/2018 to 01/31/2023


*annual cancer-related direct cost

Dr. O’Brien’s UAMS Collaborators

UAMS College of Medicine

Department of Internal Medicine

Division of Endocrinology and Metabolism

Maria Almeida, Ph.D.

Stavros Manolagas, M.D., Ph.D.

Robert Jilka, Ph.D.

Robert Weinstein, M.D.

Department of Orthopaedic Surgery

Jinhu Xiong, M.D., Ph.D.

Department of Physiology and Biophysics

Melda Onal, Ph.D.

Roy Morello, Ph.D.

Dr. O’Brien’s External Collaborators

University of Wisconsin – Madison

Department of Biochemistry

John Wesley Pike, Ph.D.

Opportunities for Collaboration

We help investigators develop novel genetically modified in vivo models. We can also help investigators measure the impact of their interventions or models on the murine skeleton.

You May Not Know That …

I enjoy skydiving and vegetable gardening.

Recent Cancer-Related Publications

Xiong, J., Cawley, KM, Piemontese, M., Fujiwara, Y., Zhao, H., Goellner, J.J., and C.A. O’Brien. Soluble RANKL contributes to osteoclast formation in adult bone but not ovariectomy-induced bone loss. Nature Communications, 9:2909, 2018. PMCID: PMC6060116

MacLeod, R.S., Cawley, K.M., Gubrij, I., Nookaew, I., Onal, M., and C.A. O’Brien. Effective CRISPR interference of an endogenous gene via a single transgene in mice. Scientific Reports, volume 9, article number 17312, 2019. doi:10.1038/s41598-019-53611-6.