January 10, 2020

Donghoon Yoon, Ph.D.

Assistant Professor
Department of Internal Medicine
UAMS College of Medicine
Faculty, Graduate Program in Interdisciplinary Biomedical Sciences

Research Interest Statement

My research is investigating the pathophysiology of multiple myeloma (MM), a B-cell cancer characterized by proliferation of malignant plasma cells in the bone marrow, presence of monoclonal serum immunoglobulin and osteolytic lesions. MM studies demonstrate that MM causes severe lytic bone lesions by enhancing osteoclast activity/suppressing osteoblast activity. We are studying the factors of bone metabolism that may influence MM growth.

We are also interested in the early detection of MM-induced bone disease (MMBD). The current methods focus on either MM cell activity or structural damage of bone. Our recent clinical observation demonstrated that a significant portion (43%) of MMBD patients heal the large bone lesions after therapy, while the rest do not. It leads us to hypothesize that MMBD patients may be cured by the treatment when captured/treated at the right disease stage. Thus the definition of MMBD staging may need to be based on the status of the osteolysis process. We employed a newly developed collagen hybridizing peptide (CHP) to detect collagen degradation that is in an early stage of the process and demonstrated that in situ imaging with CHP detects MMBD and highly correlates with MM cell numbers. Currently, we are defining the MMBD stages that CHP detects during MM development.

Additionally, we have been developing various patient-derived xenograft (PDX) in vivo models from MM, lymphoma and non-small cell lung cancer. We have developed a unique humanized in vivo strain that is susceptible to human tumor cells/tissue. We have been successfully developing various PDX models.

Dr. Yoon’s Cancer-related Grants

NIH/NCI: Univ of Utah Sub- R21OD026618

Role: Site Project PI

Title “In Situ Imaging of Collagen Degradation Activity in Multiple Myeloma and Fibrosis Murine Models”

08/15/2019 to 07/31/2021

$137,500*

*cancer-related direct cost

Dr. Yoon’s UAMS Collaborators

College of Medicine

Maurizio Zangari, M.D., Department of Internal Medicine

Shmuel Yaccoby, Ph.D., Department of Internal Medicine

Samantha Kendrick, Ph.D., Department of Biochemistry and Molecular Biology

Donald Johann Jr., M.Sc., M.D., FACP, Department of Biomedical Informatics

Dr. Yoon’s External Collaborators

Michael S. Yu, Ph.D., University of Utah

Josef T. Prchal, M.D., University of Utah

Larry J. Suva, Ph.D., Texas A&M University

Opportunities for Collaboration

I welcome all collaborations. I have extensive experience and interests in model development and in vitro differentiation to investigate the mechanisms of normo- and pathophysiology and test drugs.

You May Not Know That …

I love to explore and learn about new ethnic foods. When the weather is nice, I love to play tennis.

Recent Cancer-related Publications

  1. Bennink LL, Li Y, Kim B, Shin IJ, San BH, Zangari M, Yoon D, Yu SM, 2018, “Visualizing collagen proteolysis by peptide hybridization: From 3D cell culture to in vivo imaging,” Biomaterials, 183:67-76 DOI: 10.1016/j.biomaterials.2018.08.039. PubMed PMID: 30149231
  2. Zangari M, Yoo H, Shin IK, D Yoon, and L Suva, 2018, “Surgical Thyroparathyroidectomy Prevents Progression of 5TGM1 Murine Multiple Myeloma In Vivo,” Journal of Bone Oncology, 12: 19-22, DOI: 10.1016/j.jbo.2018.02.005
  3. Zangari M, Yoo H, Shin I, Kim B, Edmonson R, Morgan GJ, Suva LJ, and D Yoon, 2018, “Thymus-Derived Parathyroid Hormone Secretion Increases after Parathyroidectomy in C57BL6/KaLwRij mouse”, Endocrinology, 159(4): 1561-69. DOI: 10.1210/en.2017-03083
  4. Mohan M, Samant RS, Yoon D, Buros AF, Branca A, Montgomery CO, Nicholas R, Suva LJ, Morello R, Thanendrarajan S, Schinke C, Yaccoby S, van Rhee F, Davies FE, Morgan GJ, and M Zangari, 2017, “Extensive Remineralization of Large Pelvic Lytic Lesions Following Total Therapy Treatment in Patients with Multiple Myeloma”, J Bone Miner Res, DOI: 10.1002/jbmr.3111.