Spring 2016

May 6, 2016

From the Director

Gareth Morgan, M.D. FRCP, FRCPath, Ph.D

Dear Readers, The world of myeloma research is undergoing exciting advances that are changing the landscape of diagnosis and therapeutic interventions. With new drug development, creative combinations of drugs, increased understanding of how the body’s immune system can be harnessed, and the ability to define each patient’s disease at the molecular level, we can now…

From the Editor

Janet Aronson

Welcome to the inaugural issue of Myeloma, the journal of the Myeloma Center at the University of Arkansas for Medical Sciences. The goal of Myeloma is to provide timely updates about progress in clinical treatment and research advances, as well as stories and information of general interest. As a world leader in myeloma and related…

The Myeloma’s Institute Approach for Advances and a Cure

High Risk Myeloma

Innovative translational research has been at the core of the UAMS myeloma program since its inception in 1989. Translational research is research that bridges basic science with developments in clinical care.  Breakthroughs in the laboratory are translated rapidly into clinical care applications. Over the years, the Myeloma Center’s translational research concept has been to control…

Distilling Excellence

America’s largest family-owned and operated distilled spirits producer, Heaven Hill Brands, based in Louisville, Kentucky, has grown beyond its traditional roots as a Bourbon distiller to become the country’s seventh largest overall distilled spirits producer with a portfolio of innovative and relative products.

Commitment to excellence… focus on customers… ongoing improvement… ingenuity and resourcefulness… treating others with dignity and respect… nimbly adapting to new developments. These are values that help an organization perform at its best and endure. They have guided Heaven Hill Distilleries throughout its 80-year history and have ensured its success. America’s largest family-owned and operated…

New Clinical Trials

new clinical trials

A Phase II Trial of a Novel Proteasome/IMiD Combination, Ixazomib, Pomalidomide, and Dexamethasone, in Relapsed Multiple Myeloma Patients UARK 2015-03 Principal Investigator: Faith Davies, M.D. ClinicalTrials.gov Identifier: NCT02578121 The primary objective is to determine the efficacy of ixazomib when combined with pomalidomide and dexamethasone, in terms of overall response rate in patients with relapsed myeloma….

Advancing Cure with CyTOF Technology


Based on our years of experience in the research and treatment of myeloma and related diseases, we are confident that personalized approaches to treatment hold the best promise for a cure. The ability to customize treatment demands comprehensive knowledge about the nuances of each individual’s disease. With CyTOF technology, we will be able to explore…

Immune Cells of the Bone Marrow — A Brief Primer

Natural killer (NK) cells are a type of lymphocyte that directly attacks cells which have been infected by a virus.  

Bone marrow is the spongy tissue inside our bones that produces blood cells — red blood cells, platelets, and white blood cells. White blood cells help the body fight against infection. There are many different types of white blood cells, including lymphocytes, neutrophils, and monocytes. They fight against invading bacteria, viruses or fungi to help…



Monoclonal Antibody Therapy in Multiple Myeloma: Where Do We Stand and Where Are We Going? A new publication in the journal Immunotherapy (monthly peer-reviewed journal covering immunology and immunotherapy) 2016 Mar; 8 (3): 367-84 Primary Author: Sharmilan Thanendrarajan, M.D., Assistant Professor Abstract Multiple myeloma is a plasma cell malignancy that is characterized by refractory and relapsing course…

Walker brings Molecular Genetics Expertise to the Myeloma Institute

Brian Walker

Aspecialist in molecular immunology and molecular genetics, Brian Walker, Ph.D., left his native United Kingdom (UK) in October 2015 to join the Myeloma Center as professor of medicine and director of research. As a high school student in Scotland, Walker expected he would pursue a career in mathematics until “a good biology teacher changed all…

Research Grant Awarded To Dr. Schinke

Carolina Schinke

Carolina Schinke, M.D., assistant professor at the Myeloma Center, has been awarded a 2016 UAMS Medical Research Endowment Fund grant. Grants from the Medical Research Endowment Fund provide pilot research funding that has the potential to develop into extramurally funded, scientifically significant research projects. Support is focused on new areas of research for young faculty investigators…

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