Xin Li, Ph.D.

Assistant Professor of Medicine


BS, Pharmacy
China Pharmaceutical University
Nanjing, China

MS, Drug Metabolism
Zhejiang University
Zhejiang, China

PhD, Pathology and Physiology
Zhejiang University

Postgraduate Training

Post-doctoral Fellowship, Molecular Biology and Biochemistry
University of Arkansas for Medical Sciences
Little Rock, Arkansas

Post-doctoral Fellowship, Multiple Myeloma
University of Arkansas for Medical Sciences

Current Research

The generation and progression of multiple myeloma (MM) from a normal plasma cell involves a number of distinct evolving clinical phases and each phase has multiple aspects leading to myeloma. Bone marrow (BM) microenvironment is the one that continuously plays a pivotal role in the MM pathogenesis providing a sanctuary for MM cells to survive, proliferate, and resist drugs due to the existence of functional, mutual interactions between the MM cells and the BM compartments. Dr. Li’s research team is identifying cellular and molecular features which contribute to the disease progression and developing a mechanistic approach to targeted therapy for different molecular subtypes of MM. They use both in vitro and in vivo models to analyze the events associated with the interaction between MM and compartments inside bone marrow niche. Current focuses are to identify dysregulated pathways in the myeloma microenvironment and unravel molecular mechanisms of mesenchymal stem cell cytotherapy, intraclonal heterogeneity in MM, and epigenetic changes of multiple myeloma interacting with the bone marrow microenvironment by means of molecular biology, animal model, cell cultures, novel NGS technologies and data analysis using SAS, R packages, etc. 


Contact Information