NRG-GU008, also known as the “INNOVATE” study, is a clinical study for patients who have node-positive prostate cancer and need more treatment after prostatectomy. This trial compares the usual treatment of hormone therapy and radiation therapy, to apalutamide added to the usual treatment. The addition of apalutamide to the usual treatment could stabilize your cancer and prevent it from spreading. This study will help doctors learn if this different approach is better, the same, or worse than the usual approach.To decide if it is better, the study doctors will be looking to see if the study approach increases the time without prostate cancer spreading compared to the usual approach.The study drug, apalutamide, is already approved by the FDA for use in advanced prostate cancer; however, most of the time apalutamide is not used until hormone drugs stop working and after prostate cancer has spread..
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