DNA Damage and Host Response

The DNA Damage and Host Response program studies DNA repair and genomic instability in cancer and normal tissues, as well as mechanisms and interventions in adverse effects of cancer therapy. In particular, investigators are interested in genomic modifications involved in oncogenesis, resistance to therapy, and short- and long-term sequelae of radiation and chemotherapy. The long-term goal of the program is to improve cancer treatment outcomes as well as quality of life of cancer survivors.

The program has three general areas of research emphasis:

  • Identifying cancer relevant pathways involved in genomic instability and regulation
  • Defining molecular pathways leading to therapeutic resistance and tumor recurrence
  • Development of strategies to minimize side effects of cancer treatment

Program Leader

Marjan Boerma, Ph.D.