October 23, 2018

Sharp F. Malak, M.D., MPH

Associate Professor, Department of Radiology, UAMS College of Medicine

Assistant Professor, Department of Epidemiology,
UAMS Fay W. Boozman College of Public Health

Research Interest Statement

It is an honor to be a part of the first generation of physicians who are able to significantly decrease a woman’s chance of dying from breast cancer by up to fifty percent. The question of whether or not the early detection of breast cancer would reduce breast cancer mortality was answered decades ago through more than 9 million person-years of observation in randomized controlled trials conducted around the globe.

Despite the scientific evidence that early detection saves lives, the mortality reduction from screening has not been shared equally among all Americans. Certain minority groups and rural populations face educational, financial and geographic barriers to early detection, and they are more likely to present at an advanced stage and die from breast cancer.

One-third of Arkansas counties lack a mammography facility, and about 150,000 women live more than 30 minutes away from a screening facility. An estimated 275,000 women in Arkansas do not undergo annual screening with mammography as recommended, which leads our state to have one of the worst mortality/incidence ratios in the United States. Our work with the UAMS Mobile Mammography program serves to remove the aforementioned barriers to early detection while attempting to understand how to best engage women, primary care providers and communities to embrace early detection.

I am a faculty lecturer of the American College of Radiology (ACR) and Society of Breast Imaging (SBI) Breast Screening Leadership Group whose mission is to ensure that future breast imaging leaders have the knowledge and tools to understand breast cancer screening and defend it with solid science.  I also serve on the ACR Commission on Breast Imaging, Committee on Screening and Emerging Technology, and I have recently been nominated by the ACR to serve on the FDA National Mammography Quality Assurance Advisory Committee. I also serve as president of the Arkansas Radiological Society.

Grants

Arkansas Department of Health

UAMS Mobile Mammography Program; providing mammography services to underserved women in Arkansas

7/01/2018 – 6/30/2019

Principal Investigator

$401,490*

 

Susan G. Komen for the Cure, Arkansas Affiliate

 UAMS Mobile Mammography Program; providing mammography services to underserved women in the Arkansas Komen Affiliate counties

4/01/2018 – 3/31/2019

Principal Investigator

$51,877*

 

Arkansas Breast Cancer Research Foundation

Understanding the etiologic factors between cadmium exposure and mammographic density in an underserved population in Arkansas

9/1/2016 –  present

Co-Principal Investigator

$249,997*

 

Winthrop P. Rockefeller Cancer Institute Foundation

Mapping unmet demand for mammography services in Arkansas

8/01/2018 – 6/30/2019

Co-Principal Investigator

$15,640*

*cancer-related annual direct costs

Dr. Malak’s UAMS Collaborators

Don Bice, M.D.

Gwendolyn Bryant-Smith, M.D.

Anita Bucur, MPA, MBA

Jessica McElreath, M.D.

Barbara Fuhrman, Ph.D.

Ronda Henry-Tillman, M.D.

Daniela Ochoa, M.D.

Issam Makhoul, M.D.

Angela Pennisi, M.D.

Joseph Su, Ph.D., MPH

Sean Young, Ph.D.

Dr. Malak’s External Collaborators

Jay Baker, M.D. (Duke University)

Lincoln Berland, M.D. (University of Alabama)

Debra Dyer (National Jewish Health, Colorado) 

Peter Eby, M.D. (Virgina Mason)

Efren Flores, M.D. (Harvard University)

Phoebe Freer, M.D. (University of Utah)

Mark Helvie, M.D. (University of Michigan)

Ed Hendrick, Ph.D. (University of Colorado, Denver)

Daniel Kopans, M.D. (Harvard University)

Geraldine McGinty, M.D. (Weill Cornell Medical College)

Deborah Monticciolo (Baylor Scott & White)

Ed Sickles, M.D. (University of California, San Francisco)

Dana Smetherman, M.D. (Ochsner Clinic)

Judy Yee, M.D. (Albert Einstein College of Medicine)

Opportunities for Collaboration

I welcome collaboration with health policy researchers, fellow physicians and basic scientists who are interested in reducing the burden of breast cancer for women in our state and country.

You Might not Know that…

My wife Valeria, a pediatrician, and I are avid volleyball and baseball fans. Our favorite players are Victoria Malak, a freshman at Hendrix College, and Thomas Malak, a freshman at Little Rock Central High School.

Cancer-Related Publications

Berland LL, Monticciolo DL, Flores EJ, Malak SF, Yee J, Dyer DS. Relationships between Healthcare Disparities and Coverage Policies for Breast, Colon, and Lung Cancer Screening. Journal of American College of Radiology. (In Review)

Lee JY, Malak SF, Klimberg S, Henry-Tillman RS, Kadlubar SA. Change in Mammography Use Following the Revised Guidelines from the U.S. Preventive Services Task Force. The Breast Journal. 2016. doi:10.1111/tbj.12703

Ha R, Jin B, Mango V, Friedlander L, Miloshev V, Malak S, Wynn R. Breast Cancer Molecular Subtype as a Predictor of the Utility of Preoperative MRI. American Journal of Roentgenology. 2015; 204: 1354-1360.

Klimberg SV, Ochoa, D, Henry-Tillman R, Hardee M, Adkins LL, Smith M, Tummel E, Lee J, Malak SF, Makhoul I, Korourian S. Long-term Results of Phase II Ablation after Breast Lumpectomy Added to Extend Intraoperative Margins (ABLATE 1) Trial. Journal of American College of Surgeons. 2014 218 (4): 741-749.

Gadgil P, Korourian S, Malak S, Ochoa D, Lipschitz R, Henry-Tillman R, Klimberg SV. Surgeon-Performed Touch Preparation of Breast Core Needle Biopsies May Provide Accurate Same-Day Diagnosis and Expedite Treatment Planning. Annals of Surgical Oncology. December 31 2013 [epub ahead of print]: 10.1245/s10434-013-3440-5 [doi]

Erdem E, Samant R, Malak SF, Culp WC, Brown A, Peterson L, Lensing S, Barlogie B. Vertebral Augmentation in the Treatment of Pathologic compression Fractures in 792 Patients with Multiple Myeloma. Leukemia accepted article preview 3 June 2013; doi: 10.1038/leu.2013.162.

Sung JS, Malak SF, Bajaj P, Alis R, Dershaw DD, Morris EA. Screening Breast MRI in Women with a History of LCIS. Radiology. 2011: 261(2);414-420.