July 3, 2019

Igor Koturbash, M.D., Ph.D.

Associate Professor and Vice Chair
Department of Environmental and Occupational Health
Fay W. Boozman College of Public Health

Co-Director
Center for Dietary Supplements Research

Research Interest Statement

Being both M.D. and Ph.D., I have a long-lasting interest in diet and dietary supplements and their impact on human health. Therefore, the major focus of my research is safety, efficacy and mechanisms of action of dietary supplements and understanding how diet and dietary supplements can modulate tissue response to cancer therapy. I am heavily involved in a number of safety and efficacy studies on various dietary supplements and herbs, including methionine supplementation, green tea extract and cannabidiol.

Recently, I initiated the development of the Center for Dietary Supplements Research (CDSR) at UAMS. The mission of the center is to provide regulatory agencies, industry and the public with credible information, assessments, expert opinions and risk communications as well as professional and educational services relating to the efficacy and safety of dietary supplements.

Dr. Koturbash’s Cancer-Related Grants

NIH\NIGMS

Hauer-Jensen P20 Sub-Project

Epigenetic Alterations Caused by Low-Dose Ionizing Radiation

4/1/2019 to 3/31/2020

$180,000*

 

Arkansas Center for Health Disparities (ARCHD)/NIMHD Pilot Grant

Novel molecular biomarkers of previous radiation exposure and radiation-induced health effects in Northwest Arkansas Marshallese

9/1/2018 – 8/31/2019

$74,500*

Role: PI

*cancer-related annual direct cost

Dr. Koturbash’s UAMS Collaborators

UAMS College of Pharmacy

  • Division of Radiation Health, Department of Pharmaceutical Sciences
    Martin Hauer-Jensen, M.D., Ph.D.
    Marjan Boerma, Ph.D.
    Rupak Pathak, Ph.D.

UAMS College of Medicine

  • Department of Radiation Oncology
    Robert Griffin, Ph.D.
    Sanjay Maraboyina, M.D.
  • Department of Pathology and Laboratory Services
    Matthew Quick, M.D.
    Eric Yee, M.D.
  • Department of Biomedical Informatics
    David Ussery, Ph.D.
    Intawat Nookaew, Ph.D.

UAMS Fay W. Boozman College of Public Health

  • Department of Environmental and Occupational Health
    Mitchell R. McGill, Ph.D.
  • Department of Epidemiology
    Joseph Su, Ph.D., M.P.H.
  • Department of Biostatistics
    Keith Williams, Ph.D., M.P.H.
    Reid Landes, Ph.D.

Dr. Koturbash’s External Collaborators

National Center for Natural Products Research/University of Mississippi

  • Bill Gurley, Ph.D.
  • Ikhlas Khan, Ph.D.
  • Mahmoud ElSohly, Ph.D.
  • Larry Walker, Ph.D.
  • Cristina Avonto, Ph.D.

National Center for Toxicological Research, FDA
Annie Lumen, Ph.D.

Procter and Gamble
Amy Roe, Ph.D.

International Agency for Research on Cancer (Lyon, France)
Zdenko Herceg, Ph.D.

Texas A&M University
Nicolaas Deutz, M.D., Ph.D.

Harvard University
Philip Demokritou, Ph.D.

Opportunities for Collaboration

I am always open for collaborative efforts and happy to provide my knowledge and expertise in the fields of nutrition and dietary supplements.

You Might Not Know That …

I enjoy kayaking, hiking and fishing.

Recent Publications

Gurley BJ, Miousse IR, Nookaew I, Ewing LE, Skinner CM, Jenjaroenpun P, Wongsurawat T, Kennon-McGill S, Avula B, Bae JY, McGill MR, Ussery D, Khan IA, Koturbash I. Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F₁ Mice. Nutrients. 2019 Apr 3;11(4). pii: E776. doi: 10.3390/nu11040776. PMCID: PMC6521095.

Koturbash I, Griffin RJ. Harnessing epigenetics and metabolism to modulate tissue response to radiotherapy. Int J Radiat Biol. 2019 Mar 11:1-3. doi: 10.1080/09553002.2019.1587268. [Epub ahead of print] PubMed PMID: 30856046.

Ewing LE, Miousse IR, Pathak R, Skinner CM, Kosanke S, Boerma M, Hauer-Jensen M, Koturbash I. NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity. Int J Radiat Biol. 2018 Dec 18:1-21. doi: 10.1080/09553002.2018.1547437. [Epub ahead of print] PubMed PMID: 30561233.

Miousse IR, Tobacyk J, Quick CM, Jamshidi-Parsian A, Skinner CM, Kore R, Melnyk SB, Kutanzi KR, Xia F, Griffin RJ, Koturbash I. Modulation of Dietary Methionine Intake Elicits Potent, yet Distinct, Anticancer Effects on Primary Versus Metastatic Tumors. Carcinogenesis 2018 Sep 21;39(9):1117-1126. doi: 10.1093/carcin/bgy085. PubMed PMID: 29939201; PubMed Central PMCID: PMC6148987.

Miousse IR, Ewing LE, Kutanzi KR, Griffin RJ, Koturbash I. DNA Methylation in Radiation-Induced Carcinogenesis: Experimental Evidence and Clinical Perspectives. Crit Rev Oncog. 2018;23(1-2):1-11. doi: 10.1615/CritRevOncog.2018025687. PubMed PMID: 29953365.

Herceg Z, Ghantous A, Wild CP, Sklias A, Casati L, Duthie SJ, Fry R, Issa J-P, Kellermayer R, Koturbash I, Kondo Y, Lepeule J, Lima SCS, Marsit CJ, Rakyan V, Saffery R, Taylor JA, Teschendorff AE, Ushijima T, Vineis P, Walker CL, Waterland RA, Wiemels J, Ambatipudi S, Degli Esposti D, Hernandez-Vargas H. (2018) Roadmap for investigating epigenetic deregulation and environmental origins of cancer. Int J Cancer 142(5):874-882. PMID: 28836271.

Skinner CM, Miousse IR, Ewing L, Sridharan V, Cao M, Kosanke S, Lin H, Williams DK, Avula B, Haider S, Chittiboyina A, Khan I, ElSohly M, Boerma M, Gurley BJ, Koturbash I. Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE ProTM (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food Chem Toxicol 2018 Sep 30. pii: S0278-6915(18)30711-7. PMCID: PMC6219625.

Miousse IR, Pathak R, Garg S, Skinner CM, Melnyk S, Pavliv O, Hendrickson H, Landes RD, Lumen A, Tackett AJ, Deutz NEP, Hauer-Jensen M, Koturbash I. (2017) Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut, and leads to altered microbiome profiles, barrier function, gene expression and histomorphology. Genes Nutr 12:22. doi: 10.1186/s12263-017-0576-0. PMCID: PMC5588631.

Koturbash I. (2017) LINE-1 in response to exposure to ionizing radiation. Mob Genet Elements 7(6):e1393491. PMCID: PMC5706599.

Miousse IR, Kutanzi KR, Koturbash I. (2017) Effects of ionizing radiation on DNA methylation: From experimental biology to clinical applications. Int J Radiat Biol 93:457-69. PMCID: PMC5411327.