Promoting Health of Women and Future Babies
You May be Able to Make a Difference if You Have Abnormal Pap Smear Results
If you were diagnosed with high-grade squamous intraepithelial lesion (HSIL) or “cannot rule out HSIL”, you may be eligible to enroll in a clinical trial being conducted at UAMS for treating HSIL using an HPV therapeutic vaccine
Is this Study Right For You?
We are looking for women ages between 18 and 50 who were recently diagnosed with HSIL or “cannot rule out HSIL” on Pap smear. The first visit is to confirm the diagnosis of HSIL by biopsy. If HSIL is confirmed and you meet other specific criteria, you’ll be eligible to receive vaccinations (PepCan or Candin) which will be given 4 times 3 weeks apart.
You may also be eligible for vaccination if you already had a biopsy showing HSIL as long as you have not been treated. In addition, you will have study visits 6 months and 1 year after the last vaccination. If you still have HSIL after 1 year, you can choose to have loop electrical excision procedure (LEEP) or to be followed by your gynecologist. You will be told whether you received PepCan or Candin when you complete the study.
