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  6. Cancer Biology Featured Publications

Cancer Biology Featured Publications

Sabol HM, Anloague A, Kaur J, Bustamante-Gomez C, Khan S, Paxton BC, Nester MR, Hackney J, Diaz-delCastillo M, Mann D, Stambough JB, Barnes CL, Ambrogini E, Frontier A, Ebetino FH, Naqvi S, van Rhee F, Wardell CP, Drake MT, Nookaew I, Schinke C, Zangari M, Delgado-Calle J. Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition. Experimental hematology & oncology. 2025 Aug;14(1):108. doi: 10.1186/s40164-025-00699-4. PMID: 40847323; PMCID: PMC12372396.

Cannon MJ, Liu J. A Replication-Defective Myxoma Virus Inducing Pro-Inflammatory Responses as Monotherapy and an Adjuvant to Chemo- and DC Immuno-Therapy for Ovarian Cancer. Viruses. 2025 Jul;17(8). doi: 10.3390/v17081058. PMID: 40872773; PMCID: PMC12390723.

Thompson MD, Byrd AK. Untargeted CUT&Tag reads are enriched at accessible chromatin and restrict identification of potential G4-forming sequences in G4-targeted CUT&Tag experiments. Nucleic acids research. 2025 Jul;53(14). doi: 10.1093/nar/gkaf678. PMID: 40682824; PMCID: PMC12276005.

Li D, Zhang ZM, Mei L, Yu Y, Guo Y, Mackintosh SG, Chen J, Allison DF, Kim A, Storey AJ, Edmondson RD, Byrum SD, Tackett AJ, Cai L, Cook JG, Song J, Wang GG. BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication. Nature communications. 2025 Jul;16(1):5502. doi: 10.1038/s41467-025-61284-1. PMID: 40592879; PMCID: PMC12219854.

Maravelia P, Yao H, Cai C, Nascimento Silva D, Fransson J, Nilsson OB, Lu YW, Micke P, Botling J, Gatto F, Rovesti G, Carlsten M, Sallberg M, Stål P, Jorns C, Buggert M, Pasetto A. Unlocking novel T cell-based immunotherapy for hepatocellular carcinoma through neoantigen-driven T cell receptor isolation. Gut. 2025 Jun;74(7):1125-1136. doi: 10.1136/gutjnl-2024-334148. PMID: 39832892; PMCID: PMC12611799.

Delgado-Calle J. Unlocking acid ceramidase: a new weapon against proteasome chemoresistance in myeloma. Haematologica. 2025 Jun;110(6):1248-1249. doi: 10.3324/haematol.2024.286925. PMID: 39744827; PMCID: PMC12130778.

Sun F, Cheng Y, Ma C, Xu H, Bailey C, Mery D, Ashby TC, Alapat D, Li Y, Young KH, Al Hadidi S, Thanendrarajan S, Schinke C, Zangari M, van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F. Polyclonal plasma cell (PolyPC) signature as a key indicator for predicting the progression of MGUS to multiple myeloma. Cancer biomarkers : section A of Disease markers. 2025 Jun;42(6):18758592251344936. doi: 10.1177/18758592251344936. PMID: 40485257; PMCID: PMC12288413.

Qin L, Moreno Rueda LY, Ray U, Mahmud I, Tan L, Lorenzi PL, Liu S, Lin HY, Mery DE, Zhan F, Shaughnessy JD Jr, Yi Q, Acevedo Calado MJ, Wang H, Manasanch EE, Lee HC, Patel KK, Kuiatse I, Symer DE, Orlowski RZ. Targeting caseinolytic mitochondrial matrix peptidase, a novel contributor to the pathobiology of high-risk multiple myeloma. Blood. 2025 May;145(22):2614-2629. doi: 10.1182/blood.2024024781. PMID: 39912779; PMCID: PMC12163742.

Anloague A, Sabol HM, Kaur J, Khan S, Ashby C, Schinke C, Barnes CL, Alturkmani F, Ambrogini E, Gundesen MT, Lund T, Amstrup AK, Andersen TL, Diaz-delCastillo M, Roodman GD, Bellido T, Delgado-Calle J. A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma. Haematologica. 2025 Apr;110(4):952-966. doi: 10.3324/haematol.2024.286484. PMID: 39605211; PMCID: PMC11959238.

Ahn JH, Guo Y, Lyons H, Mackintosh SG, Lau BK, Edmondson RD, Byrum SD, Storey AJ, Tackett AJ, Cai L, Sabari BR, Wang GG. The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators. Molecular cell. 2025 Feb;85(4):708-725.e9. doi: 10.1016/j.molcel.2024.12.026. PMID: 39922194; PMCID: PMC12224276.

Moreno Rueda LY, Wang H, Akagi K, Dang M, Vora A, Qin L, Lee HC, Patel KK, Lin P, Mery DE, Zhan F, Shaughnessy JD Jr, Yi Q, Jiang B, Gillison ML, Thomas SK, Weber DM, Diao L, Wang J, Kuiatse I, Manasanch EE, Symer DE, Orlowski RZ. Single-cell analysis of neoplastic plasma cells identifies myeloma pathobiology mediators and potential targets. Cell reports. Medicine. 2025 Feb;6(2):101925. doi: 10.1016/j.xcrm.2024.101925. PMID: 39855192; PMCID: PMC11866523.

West KL, Nguyen TTN, Tengler KA, Kreiling N, Raney KD, Ghosal G, Leung JW. Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction. Nucleic acids research. 2025 Feb;53(4). doi: 10.1093/nar/gkae1279. PMID: 39727191; PMCID: PMC11879137.

Owens SM, Sifford JM, Li G, Murdock SJ, Salinas E, Oldenburg D, Ghosh D, Stumhofer JS, Nookaew I, Manzano M, Forrest JC. Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment. Nature communications. 2025 Jan;16(1):951. doi: 10.1038/s41467-025-56247-5. PMID: 39843898; PMCID: PMC11754798.

Xia J, Zhao H, Edmondson JL, Koss B, Zhan F. Role of NEK2 in tumorigenesis and tumor progression. Trends in molecular medicine. 2025 Jan;31(1):79-93. doi: 10.1016/j.molmed.2024.07.013. PMID: 39181803; PMCID: PMC11717647.

Kaur J, Delgado-Calle J. Ex Vivo Model Systems of Cancer-Bone Cell Interactions. Methods in molecular biology (Clifton, N.J.). 2025 Jan;2885:291-302. doi: 10.1007/978-1-0716-4306-8_14. PMID: 40448766; PMCID: PMC12330813.

Kaur J, Adhikari M, Sabol HM, Anloague A, Khan S, Kurihara N, Diaz-delCastillo M, Andreasen CM, Barnes CL, Stambough JB, Palmieri M, Reyes-Castro O, Zarrer J, Taipaleenmäki H, Ambrogini E, Almeida M, O’Brien C, Nookaew I, Delgado-Calle J. Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis. Cancer research. 2024 Dec;84(23):3936-3952. doi: 10.1158/0008-5472.CAN-24-0857. PMID: 39312185; PMCID: PMC11611663.

Cheng Y, Sun F, Alapat DV, Wanchai V, Mery D, Siegel ER, Xu H, Johnson S, Guo W, Bailey C, Ashby C, Bauer MA, Hadidi SA, Schinke C, Thanendrarajan S, Zangari M, van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F. Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages. Blood cancer journal. 2024 Nov;14(1):194. doi: 10.1038/s41408-024-01172-x. PMID: 39505839; PMCID: PMC11541562.

Sabol HM, Ashby C, Adhikari M, Anloague A, Kaur J, Khan S, Choudhury SR, Schinke C, Palmieri M, Barnes CL, Ambrogini E, Nookaew I, Delgado-Calle J. A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma. Haematologica. 2024 Aug;109(8):2606-2618. doi: 10.3324/haematol.2023.284443. PMID: 38385272; PMCID: PMC11290536.

Leung YK, Lee SG, Wang J, Guruvaiah P, Rusch NJ, Ho SM, Park C, Kim K. The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-β catenin-p300 Interactions in Hepatocellular Carcinoma. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024 Aug;11(29):e2308539. doi: 10.1002/advs.202308539. PMID: 38790135; PMCID: PMC11304255.

Hong Z, Byrd AK, Gao J, Das P, Tan VQ, Malone EG, Osei B, Marecki JC, Protacio RU, Wahls WP, Raney KD, Song H. Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge. Nature communications. 2024 Jul;15(1):6104. doi: 10.1038/s41467-024-50575-8. PMID: 39030241; PMCID: PMC11275212.

Xian M, Wang Q, Xiao L, Zhong L, Xiong W, Ye L, Su P, Zhang C, Li Y, Orlowski RZ, Zhan F, Ganguly S, Zu Y, Qian J, Yi Q. Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis. Nature communications. 2024 Jul;15(1):5767. doi: 10.1038/s41467-024-50073-x. PMID: 38982045; PMCID: PMC11233649.

Gao J, Proffitt DR, Marecki JC, Protacio RU, Wahls WP, Byrd AK, Raney KD. Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth. Nucleic acids research. 2024 Jun;52(11):6543-6557. doi: 10.1093/nar/gkae403. PMID: 38752483; PMCID: PMC11194084.

Marino S, Petrusca DN, Bishop RT, Anderson JL, Sabol HM, Ashby C, Layer JH, Cesarano A, Davé UP, Perna F, Delgado-Calle J, Chirgwin JM, Roodman GD. Pharmacologic targeting of the p62 ZZ domain enhances both anti-tumor and bone-anabolic effects of bortezomib in multiple myeloma. Haematologica. 2024 May;109(5):1501-1513. doi: 10.3324/haematol.2023.283787. PMID: 37981834; PMCID: PMC11063840.

Marin LP, Presley JH, Noori K, McKinstry D, Dawson B, Sexton K, Peterson E, Harrington SE, Gardner JM, Nagalo BM, Montzavi-Karbassi B, Post SR, Nicholas RW, Kelly T. Partnership in Cancer Research (PCAR) Program Increases Medical Student Knowledge and Confidence to Perform Cancer Research. Journal of cancer education : the official journal of the American Association for Cancer Education. 2024 Apr;39(2):111-117. doi: 10.1007/s13187-023-02383-9. PMID: 37957501; PMCID: PMC10995089.

Li JR, Arsang-Jang S, Cheng Y, Sun F, D’Souza A, Dhakal B, Hari P, Huang Q, Auer P, Li Y, Urrutia R, Zhan F, Shaughnessy JD Jr, Janz S, Dong J, Cheng C. Enhancing prognostic power in multiple myeloma using a plasma cell signature derived from single-cell RNA sequencing. Blood cancer journal. 2024 Mar;14(1):38. doi: 10.1038/s41408-024-01024-8. PMID: 38443358; PMCID: PMC10915134.

McCrury M, Swafford K, Shuttleworth SL, Mehdi SH, Acharya B, Saha D, Naceanceno K, Byrum SD, Storey AJ, Xu YZ, Doshier C, Patel V, Post GR, De Loose A, Rodriguez A, Shultz LD, Zhan F, Yoon D, Frett B, Kendrick S. Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma. Molecular cancer therapeutics. 2024 Mar;23(3):316-329. doi: 10.1158/1535-7163.MCT-23-0299. PMID: 37816504; PMCID: PMC10932871.

Sun F, Cheng Y, Wanchai V, Guo W, Mery D, Xu H, Gai D, Siegel E, Bailey C, Ashby C, Al Hadidi S, Schinke C, Thanendrarajan S, Ma Y, Yi Q, Orlowski RZ, Zangari M, van Rhee F, Janz S, Bishop G, Tricot G, Shaughnessy JD Jr, Zhan F. Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth. Nature communications. 2024 Jan;15(1):615. doi: 10.1038/s41467-024-44873-4. PMID: 38242888; PMCID: PMC10798961.

Sun F, Cheng Y, Chen JR, Wanchai V, Mery DE, Xu H, Gai D, Al Hadidi S, Schinke C, Thanendrarajan S, Zangari M, van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F. BCMA- and CST6-specific CAR T cells lyse multiple myeloma cells and suppress murine osteolytic lesions. The Journal of clinical investigation. 2024 Jan;134(1). doi: 10.1172/JCI171396. PMID: 37883186; PMCID: PMC10760955.

Luo Y, Shreeder B, Jenkins JW, Shi H, Lamichhane P, Zhou K, Bahr DA, Kurian S, Jones KA, Daum JI, Dutta N, Necela BM, Cannon MJ, Block MS, Knutson KL. Th17-inducing dendritic cell vaccines stimulate effective CD4 T cell-dependent antitumor immunity in ovarian cancer that overcomes resistance to immune checkpoint blockade. Journal for immunotherapy of cancer. 2023 Nov;11(11). doi: 10.1136/jitc-2023-007661. PMID: 37918918; PMCID: PMC10626769.

Zhao S, Lu J, Pan B, Fan H, Byrum SD, Xu C, Kim A, Guo Y, Kanchi KL, Gong W, Sun T, Storey AJ, Burkholder NT, Mackintosh SG, Kuhlers PC, Edmondson RD, Strahl BD, Diao Y, Tackett AJ, Raab JR, Cai L, Song J, Wang GG. TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons. Nature. 2023 Nov;623(7987):633-642. doi: 10.1038/s41586-023-06688-z. PMID: 37938770; PMCID: PMC11000523.

Cheng Y, Sun F, Alapat DV, Wanchai V, Mery D, Guo W, Cao H, Zhu Y, Ashby C, Bauer MA, Nookaew I, Siegel ER, Ying J, Chen JR, Gai D, Peng B, Xu H, Bailey C, Al Hadidi S, Schinke C, Thanendrarajan S, Zangari M, Chesi M, Bergsagel PL, van Rhee F, Janz S, Tricot G, Shaughnessy JD Jr, Zhan F. High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma. Cell reports. Medicine. 2023 Oct;4(10):101214. doi: 10.1016/j.xcrm.2023.101214. PMID: 37794587; PMCID: PMC10591052.

Wan L, Lin KT, Rahman MA, Ishigami Y, Wang Z, Jensen MA, Wilkinson JE, Tuveson DA, Krainer AR. Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer. Cancer discovery. 2023 Jul;13(7):1678-1695. doi: 10.1158/2159-8290.CD-22-1013. PMID: 37098965; PMCID: PMC10330071.

Alam J, Huda MN, Tackett AJ, Miah S. Oncogenic signaling-mediated regulation of chromatin during tumorigenesis. Cancer metastasis reviews. 2023 Jun;42(2):409-425. doi: 10.1007/s10555-023-10104-3. PMID: 37147457; PMCID: PMC10348982.

Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H, Kumthekar PU, Chen CC, Aiken R, Groves MD, Ong SS, Ramakrishna R, Vogelbaum MA, Khagi S, Kaley T, Melear JM, Peereboom DM, Rodriguez A, Yankelevich M, Nair SG, Puduvalli VK, Aldape K, Gao A, López-Janeiro Á, de Andrea CE, Alonso MM, Boutros P, Robbins J, Mason WP, Sonabend AM, Stupp R, Fueyo J, Gomez-Manzano C, Lang FF, Zadeh G. Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial. Nature medicine. 2023 Jun;29(6):1370-1378. doi: 10.1038/s41591-023-02347-y. PMID: 37188783; PMCID: PMC10287560.

Anloague A, Delgado-Calle J. Osteocytes: New Kids on the Block for Cancer in Bone Therapy. Cancers. 2023 May;15(9). doi: 10.3390/cancers15092645. PMID: 37174109; PMCID: PMC10177382.

Kuehnle N, Osborne SM, Liang Z, Manzano M, Gottwein E. CRISPR screens identify novel regulators of cFLIP dependency and ligand-independent, TRAIL-R1-mediated cell death. Cell death and differentiation. 2023 May;30(5):1221-1234. doi: 10.1038/s41418-023-01133-0. PMID: 36801923; PMCID: PMC10154404.

Gai D, Chen JR, Stewart JP, Nookaew I, Habelhah H, Ashby C, Sun F, Cheng Y, Xu H, Peng B, Garg TK, Schinke C, Thanendrarajan S, Zangari M, Chen F, Barlogie B, van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F. CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation. The Journal of clinical investigation. 2022 Sep;132(18). doi: 10.1172/JCI159527. PMID: 35881476; PMCID: PMC9479617.

Conrad SJ, Raza T, Peterson EA, Liem J, Connor R, Nounamo B, Cannon M, Liu J. Myxoma virus lacking the host range determinant M062 stimulates cGAS-dependent type 1 interferon response and unique transcriptomic changes in human monocytes/macrophages. PLoS pathogens. 2022 Sep;18(9):e1010316. doi: 10.1371/journal.ppat.1010316. PMID: 36103568; PMCID: PMC9473615.

Eliason S, Hong L, Sweat Y, Chalkley C, Cao H, Liu Q, Qi H, Xu H, Zhan F, Amendt BA. Extracellular vesicle expansion of PMIS-miR-210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism. Clinical and translational medicine. 2022 Sep;12(9):e1037. doi: 10.1002/ctm2.1037. PMID: 36116139; PMCID: PMC9482803.

Kim SP, Vale NR, Zacharakis N, Krishna S, Yu Z, Gasmi B, Gartner JJ, Sindiri S, Malekzadeh P, Deniger DC, Lowery FJ, Parkhurst MR, Ngo LT, Ray S, Li YF, Hill V, Florentin M, Masi RV, Paria BC, Levin N, Bera A, Hedges EA, Choi A, Chatani PD, Parikh AY, Levi S, Seitter S, Lu YC, Zheng Z, Prickett TD, Jia L, Hernandez JM, Hoang CD, Robbins PF, Goff SL, Sherry RM, Yang JC, Rosenberg SA. Adoptive Cellular Therapy with Autologous Tumor-Infiltrating Lymphocytes and T-cell Receptor-Engineered T Cells Targeting Common p53 Neoantigens in Human Solid Tumors. Cancer immunology research. 2022 Aug;10(8):932-946. doi: 10.1158/2326-6066.CIR-22-0040. PMID: 35749374; PMCID: PMC9357191.

Sabol HM, Amorim T, Ashby C, Halladay D, Anderson J, Cregor M, Sweet M, Nookaew I, Kurihara N, Roodman GD, Bellido T, Delgado-Calle J. Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction. Neoplasia (New York, N.Y.). 2022 Jun;28:100785. doi: 10.1016/j.neo.2022.100785. PMID: 35390742; PMCID: PMC8990177.

Liu J, Wang X, Chen AT, Gao X, Himes BT, Zhang H, Chen Z, Wang J, Sheu WC, Deng G, Xiao Y, Zou P, Zhang S, Liu F, Zhu Y, Fan R, Patel TR, Saltzman WM, Zhou J. ZNF117 regulates glioblastoma stem cell differentiation towards oligodendroglial lineage. Nature communications. 2022 Apr;13(1):2196. doi: 10.1038/s41467-022-29884-3. PMID: 35459228; PMCID: PMC9033827.

Lowery FJ, Krishna S, Yossef R, Parikh NB, Chatani PD, Zacharakis N, Parkhurst MR, Levin N, Sindiri S, Sachs A, Hitscherich KJ, Yu Z, Vale NR, Lu YC, Zheng Z, Jia L, Gartner JJ, Hill VK, Copeland AR, Nah SK, Masi RV, Gasmi B, Kivitz S, Paria BC, Florentin M, Kim SP, Hanada KI, Li YF, Ngo LT, Ray S, Shindorf ML, Levi ST, Shepherd R, Toy C, Parikh AY, Prickett TD, Kelly MC, Beyer R, Goff SL, Yang JC, Robbins PF, Rosenberg SA. Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers. Science (New York, N.Y.). 2022 Feb;375(6583):877-884. doi: 10.1126/science.abl5447. PMID: 35113651; PMCID: PMC8996692.

Delgado-Calle J, Bellido T. The osteocyte as a signaling cell. Physiological reviews. 2022 Jan;102(1):379-410. doi: 10.1152/physrev.00043.2020. PMID: 34337974; PMCID: PMC8858675.

Paidi SK, Troncoso JR, Harper MG, Liu Z, Nguyen KG, Ravindranathan S, Rebello L, Lee DE, Ivers JD, Zaharoff DA, Rajaram N, Barman I. Raman spectroscopy reveals phenotype switches in breast cancer metastasis. Theranostics. 2022 Jan;12(12):5351-5363. doi: 10.7150/thno.74002. PMID: 35910801; PMCID: PMC9330538.

Chen J, Song J, James J, Plaisance-Bonstaff K, Post SR, Qin Z, Dai L. Activation of IL1 signaling molecules by Kaposi’s sarcoma-associated herpesvirus. Frontiers in cellular and infection microbiology. 2022 Jan;12:1049624. doi: 10.3389/fcimb.2022.1049624. PMID: 36457850; PMCID: PMC9705745.

Paidi SK, Rajaram N, Raj P, Bordett R, Zhang C, Karandikar SH, Pandey R, Barman I. Raman and quantitative phase imaging allow morpho-molecular recognition of malignancy and stages of B-cell acute lymphoblastic leukemia. Biosensors & bioelectronics. 2021 Oct;190:113403. doi: 10.1016/j.bios.2021.113403. PMID: 34130086; PMCID: PMC8492164.

Sabol HM, Ferrari AJ, Adhikari M, Amorim T, McAndrews K, Anderson J, Vigolo M, Lehal R, Cregor M, Khan S, Cuevas PL, Helms JA, Kurihara N, Srinivasan V, Ebetino FH, Boeckman RK, Roodman GD, Bellido T, Delgado-Calle J. Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity. Cancer research. 2021 Oct;81(19):5102-5114. doi: 10.1158/0008-5472.CAN-21-0524. PMID: 34348968; PMCID: PMC8488008.

Xia J, Franqui Machin R, Chen F, He Y, Ashby TC, Teng F, Xu H, Liu D, Gai D, Johnson SK, van Rhee F, Janz S, Shaughnessy JD Jr, Tricot G, Frech I, Zhan F. TRIP13 modulates protein deubiquitination and accelerates tumor development and progression of B cell malignancies. The Journal of clinical investigation. 2021 Jul;131(14). doi: 10.1172/JCI146893. PMID: 34061780; PMCID: PMC8279583.

Leko V, Cafri G, Yossef R, Paria B, Hill V, Gurusamy D, Zheng Z, Gartner JJ, Prickett TD, Goff SL, Robbins P, Lu YC, Rosenberg SA. Identification of neoantigen-reactive T lymphocytes in the peripheral blood of a patient with glioblastoma. Journal for immunotherapy of cancer. 2021 Jul;9(7). doi: 10.1136/jitc-2021-002882. PMID: 34266885; PMCID: PMC8286793.

Lu YC, Zheng Z, Lowery FJ, Gartner JJ, Prickett TD, Robbins PF, Rosenberg SA. Direct identification of neoantigen-specific TCRs from tumor specimens by high-throughput single-cell sequencing. Journal for immunotherapy of cancer. 2021 Jul;9(7). doi: 10.1136/jitc-2021-002595. PMID: 34321276; PMCID: PMC8320258.

Gu C, Wang W, Tang X, Xu T, Zhang Y, Guo M, Wei R, Wang Y, Jurczyszyn A, Janz S, Beksac M, Zhan F, Seckinger A, Hose D, Pan J, Yang Y. CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma. Molecular cancer. 2021 Jun;20(1):84. doi: 10.1186/s12943-021-01380-0. PMID: 34090465; PMCID: PMC8178856.

Adhikari M, Delgado-Calle J. Role of Osteocytes in Cancer Progression in the Bone and the Associated Skeletal Disease. Current osteoporosis reports. 2021 Jun;19(3):247-255. doi: 10.1007/s11914-021-00679-7. PMID: 33818732; PMCID: PMC8486016.

Paidi SK, Rajaram N, Shah V, Raj P, Glunde K, Pandey R, Barman I. Coarse Raman and optical diffraction tomographic imaging enable label-free phenotyping of isogenic breast cancer cells of varying metastatic potential. Biosensors & bioelectronics. 2021 Mar;175:112863. doi: 10.1016/j.bios.2020.112863. PMID: 33272866; PMCID: PMC7847362.

Ketkar A, Smith L, Johnson C, Richey A, Berry M, Hartman JH, Maddukuri L, Reed MR, Gunderson JEC, Leung JWC, Eoff RL. Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs. Nucleic acids research. 2021 Feb;49(4):2065-2084. doi: 10.1093/nar/gkab041. PMID: 33555350; PMCID: PMC7913688.

Yuan Y, Raj P, Siddhanta S, Barman I, Bulte JWM, Rajaram N. Furin-Mediated Self-Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors. Angewandte Chemie (International ed. in English). 2021 Feb;60(8):3923-3927. doi: 10.1002/anie.202014839. PMID: 33325142; PMCID: PMC7902394.

Boyle EM, Deshpande S, Tytarenko R, Ashby C, Wang Y, Bauer MA, Johnson SK, Wardell CP, Thanendrarajan S, Zangari M, Facon T, Dumontet C, Barlogie B, Arbini A, Rustad EH, Maura F, Landgren O, Zhan F, van Rhee F, Schinke C, Davies FE, Morgan GJ, Walker BA. The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma. Nature communications. 2021 Jan;12(1):293. doi: 10.1038/s41467-020-20524-2. PMID: 33436579; PMCID: PMC7804406.

Edwards AD, Marecki JC, Byrd AK, Gao J, Raney KD. G-Quadruplex loops regulate PARP-1 enzymatic activation. Nucleic acids research. 2021 Jan;49(1):416-431. doi: 10.1093/nar/gkaa1172. PMID: 33313902; PMCID: PMC7797039.

Lee DE, Brown JL, Rosa-Caldwell ME, Perry RA, Brown LA, Haynie WS, Washington TA, Wiggs MP, Rajaram N, Greene NP. Cancer-induced Cardiac Atrophy Adversely Affects Myocardial Redox State and Mitochondrial Oxidative Characteristics. JCSM rapid communications. 2021 Jan;4(1):3-15. doi: 10.1002/rco2.18. PMID: 33693448; PMCID: PMC7939061.

Sabol HM, Delgado-Calle J. The multifunctional role of Notch signaling in multiple myeloma. Journal of cancer metastasis and treatment. 2021 Jan;7. doi: 10.20517/2394-4722.2021.35. PMID: 34778567; PMCID: PMC8589324.

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