Cancer Therapeutics

The mission of the Cancer Therapeutics Program is to optimize therapies through the generation, integration and translation of scientific information between the bench and the bedside, the patient and the population.

Specific Aims: The overarching goal of the Cancer Therapeutics Program is the development of novel therapeutics and biomarkers to improve cancer treatment. To achieve this goal, research in the Cancer Therapeutics Program has the following aims:

• Aim 1: Facilitate the discovery, delivery and preclinical evaluation of therapeutics to molecular targets identified by cancer center members.
• Aim 2: Identify, validate and test biomarkers and informatics approaches for the preclinical development of novel therapeutics.
• Aim 3: Support the design and conduct of innovative clinical trials in support of local therapeutic development.

1. Birrer MJ, Moore KN, Betella I, Bates RC. Antibody-drug conjugate-based therapeutics: State of the science. Journal of the National Cancer Institute. 2019 Jun 1;111(6):538-549. PMID: 30859213.
2. Dillmon MS, Kennedy EB, Anderson MK, Brodersen M, Cohen H, D Amato SL, Davis P, Doshi G, Genschaw S, Makhoul I, Ormsby W, Panikkar R, Peng E, Raez LE, Ronnen EA, Wimbiscus B, Reff M. Patient-Centered Standards for Medically Integrated Dispensing: ASCO/NCODA Standards. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2020;38(6): 633-644.
3. Fajgenbaum DC, Wu D, Goodman A, Wong R, Chadburn A, Nasta S, Srkalovic G, Mukherjee S, Leitch H, Jayanthan R, Ferrero S, Sato Y, Schey S, Dispenzieri A, Oksenhendler E, Zinzani PL, Lechowicz MJ, Hoffmann C, Pemmaraju N, Bagg A, Fossa A, Lim MS, van Rhee F. Insufficient evidence exists to use histopathologic subtype to guide treatment of idiopathic multicentric Castleman disease. American journal of hematology. 2020;():
4. Galanzha EI, Menyaev YA, Yadem AC, Sarimollaoglu M, Juratli MA, Nedosekin DA, Foster SR, Jamshidi-Parsian A, Siegel ER, Makhoul I, Hutchins LF, Suen JY, Zharov VP. In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma. Science translational medicine. 2019;11(496).
5. Jenjaroenpun P, Wongsurawat T, Wadley TD, Wassenaar TM, Liu J, Dai Q, Wanchai V, Akel NS, Jamshidi-Parsian A, Franco AT, Boysen G, Jennings ML, Ussery DW, He C, Nookaew I. Decoding the epitranscriptional landscape from native RNA sequences. Nucleic acids research. 2020.
6. Yan W, Lakkaniga NR, Carlomagno F, Santoro M, McDonald NQ, Lv F, Gunaganti N, Frett B, Li HY. Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application. Journal of medicinal chemistry. 2019;62(4): 1731-1760.