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Winthrop P. Rockefeller Cancer Institute: Research
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  1. University of Arkansas for Medical Sciences
  2. Winthrop P. Rockefeller Cancer Institute
  3. Research
  4. Research Resources
  5. Shared Resources
  6. Translational Pathology

Translational Pathology

Overview of Services

The Translational Pathology Shared Resource at the University of Arkansas for Medical Sciences is comprised of the Experimental Pathology Core and the Tissue Biorepository and Procurement Service (TBAPS).

The UAMS Experimental Pathology (ExPath) Core Laboratory provides researchers with centralized, comprehensive histological services. The laboratory can process and paraffin embed tissues, and section frozen and paraffin-embedded tissues for use in biochemical, molecular, and pathologic studies. The laboratory works with investigators to develop immunostaining approaches to detect specific targets of interest, and to identify clinical pathologists who can assist with image analysis and data interpretation.

The UAMS Tissue Biorepository and Procurement Service (TBAPS) is a repository of human specimens accessible to the UAMS research community. TBAPS uses an IRB approved protocol and general consent form to consent patients, acquire samples from the pathology grossing room, and provide samples to researchers who have appropriate approval. Solid tissues and fluid specimens are stored in liquid nitrogen tanks. Solid tissues may also be embedded into paraffin. De-identified sample and related pathology data are available for a variety of organs.

Services

Experimental Pathology Core Laboratory

  • Tissue processing and embedding
  • Tissue sectioning (frozen and paraffin-embedded)
  • Tissue staining (H&E, immunohistochemical, immunofluorescent, and special stains)
  • Digital slide scanning
  • Multispectral imaging and analysis
  • Pathology consultation

Tissue Biorepository and Procurement Service

  • Collection of solid tissue specimens (fresh, snap-frozen, and/or paraffin-embedded) and fluid specimens (serum and urine)
  • Project specific tissue procurement and storage
  • Assist with patient consenting
  • Consult on protocol development for tissue acquisition
  • Specimen management using secure, web-based data management software (caTissue Suite)

Equipment

Experimental Pathology

Processing: Tissue-Tek VIP E300 Tissue Processor

Embedding: Tissue-Tek Embedding Center

Sectioning: Microm HM505E Cryostat, Microm HM325 Rotary Microtome

Staining: Histo-Tek SL Automated Slide Stainer, Tissue-Tek Glas Automated Glass Coverslipper, Leica Bond-Rx Fully Automated Research Stainer

Imaging:  Digital imaging and analysis of slides are available using an Aperio Scanscope CS coupled with ImageScope Slide Viewer and Image Analysis software from Leica. Available analysis algorithms include color deconvolution, nuclear and membrane localization, and quantifying positive pixel number and intensity

Phenoptics™ analysis is available using the Mantra™ Quantitative Pathology Workstation, which is a manual microscope equipped with a multispectral camera and inForm® image analysis software. Phenoptics integrates multiplexed immunohistochemistry and imaging to quantitatively capture systems biology data with cellular detail. It reveals multi-parameter cellular expressions and interactions while retaining spatial context, offering insights into the complexity of tissue biology.

Tissue Biorepository and Procurement Service

  • Over 8000 patients consented
  • Over 20,000 samples banked
  • 9 liqN2 freezers
  • 2  -80 ℃ freezers 
  • Domino/MAPI straw system for aliquoting liquid samples
  • Equipment for sample processing

Contacts

Steven Post, PhD              
Director 
501-526-6046
spost@uams.edu
Biomed 2, 609-2 

Jennifer James, BS, HTL(ASCP), QIHC, CRS   
Experimental Pathology Project Manager
501-686-8265
JamesJenniferD@uams.edu
Cancer Institute Walker Tower, 429

Rémelle Eggerson, BS, CRS
TBAPS Project Manager 
501-686-7470
EggersonRemelleM@uams.edu
Cancer Institute Walker Tower, 406

Winthrop P. Rockefeller Cancer Institute LogoWinthrop P. Rockefeller Cancer InstituteWinthrop P. Rockefeller Cancer Institute
Address: 449 Jack Stephens Dr., Little Rock, AR 72205
Parking Deck: 4018 W Capitol Ave, Little Rock, AR 72205
Appointments: (501) 296-1200
Referring Physicians: (501) 686-6080
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