As a cancer survivor, Dr. Wolfe brings a passion to pancreatic cancer research that few others can. A recent recipient of a TRI Career Development Award, Wolfe is investigating the role of oncogenic KRAS in regulating the DNA repair of RAD18, an enzyme with a major role in pancreatic cancer DNA repair.
What is your relationship to cancer? How did you become involved in cancer research?
My journey to becoming an oncology physician and cancer researcher has been ongoing for nearly 20 years. After a personal bout with cancer in high school, I decided early on that I wanted to dedicate my career (and life) to helping cancer patients. I discovered that I was both passionate about laboratory research and clinical care, so I earned a dual M.D./Ph.D. My current research focus is on discovering novel therapeutic strategies for the deadly disease of pancreatic cancer. In the lab, I use genetic and proteomic approaches to address the fundamental mechanisms of genetic alterations in cancer cells which result in heightened DNA repair leading to radiation and chemotherapy resistance. I was recently awarded the UAMS Translational Research Institute’s KL2 Mentored Career Development Award to investigate the mechanism underlying the role of oncogenic KRAS in regulating the nuclear DNA repair enzyme RAD18, a major promoter of DNA repair in pancreatic cancer.
What do you hope to contribute to the UAMS Cancer Institute?
It is an honor to be joining the UAMS Cancer Institute as a physician-scientist in Radiation Oncology. I believe that I will contribute to the overall goals of the Cancer Institute which include development of novel treatment strategies for the deadly disease of pancreatic cancer, provide compassionate and excellent care for our cancer patients, and perform and publish translational cancer research and obtain research funding. All of these contributions will help propel UAMS to our goal of NCI designation.
More about Adam Wolfe, M.D., Ph.D.
I joined the Winthrop P. Rockefeller Cancer Institute in July 2021 after completing my residency in Radiation Oncology at Ohio State University (OSU). There, I completed a Holman Fellowship researching DNA repair mechanisms of resistance in pancreatic and thyroid cancers. I was awarded research funding from both the Radiation Oncology Institute and the Radiological Society of North America during my fellowship at OSU. I received dual M.D. and Ph.D. degrees from the Medical Scientist Training Program at The University of Texas McGovern Medical School and MD Anderson Cancer Center Graduate School of Biomedical Sciences in 2016.
View Dr. Wolfe’s page on the Cancer Institute Research Directory