Dr. DelNero is an assistant professor with the Division of Community Health and Research in the Department of Internal Medicine at the University of Arkansas for Medical Sciences (UAMS). His research involves implementation science, community engagement and biomedical engineering.

DelNero studies the connection between the Cancer Institute and the catchment area. The ‘catchment area’ refers to the geographic area that UAMS serves in its research, treatment and outreach. The catchment area provides a geographic scope to monitor cancer trends, identify pronounced disparities and enact cancer control strategies. Information about the catchment area can improve the implementation of evidence-based programs to reduce the burden of cancer. A better understanding of the catchment area ensures that all segments of the population benefit from advances in cancer prevention, early detection, treatment and survivorship care.

DelNero also studies the relationship between blood vessels and cancer metabolism. He developed “tumor-on-a-chip” devices to investigate tissue perfusion and cell energy status. His research contributed to new strategies to predict whether patients are likely to benefit from drugs that target specific metabolic pathways.

DelNero completed a postdoc with the Implementation Science team in the Division of Cancer Control and Population Sciences at the National Cancer Institute. He earned a bachelor’s degree in chemical engineering at Vanderbilt, a Master’s in Public Health at Harvard and a Ph.D. in biomedical engineering at Cornell. His articles appeared in CEBP, Nature Protocols, Science Translational Medicine, Advanced Drug Delivery Reviews and Biomaterials.

DelNero is originally from Kansas. Outside of lab, he enjoys spending time with friends and family. His hobbies include baking and running. Last month, he hiked the Ozark Highland Trail and fell in love with the Arkansas mountains. He is excited to join the team at UAMS!

pdelnero@uams.edu
(501) 526-4340
CI-10166

Assistant Professor
Pediatric Hematology and Oncology
Department of Pediatrics, UAMS College of Medicine
Arkansas Children’s Research Institute

What is your relationship to cancer?

As described by Dr. Siddhartha Mukherjee in his Pulitzer Prize winning monograph, cancer is and continues to be “The Emperor of All Maladies”. Being diagnosed with cancer is always scary for obvious reasons. Not only it is difficult to diagnose, treat and experience, it is also difficult to describe. Cancer is not one disease, but a collective name for what can happen when our body’s chemical instruction manual goes wrong.

I have my training and experience in biological engineering and had no concrete plan to pursue cancer research. During my training at the Cancer Institute, I first came in close contact with cancer patients, while sharing the elevators or getting foods at the cafeteria. I was deeply saddened to see the painful faces, their struggle to walk freely like a healthy individual, and a silent fear in the eyes of their family. This gradually changed my perception and motivated me to steer my interest to cancer research where my efforts and skillset could ultimately have an important impact in the lives of cancer patients and their families.

What do you hope to contribute as a member of the Winthrop P. Rockefeller Cancer Institute?

Arkansas Children’s Research Institute and UAMS provided me with a unique opportunity to invest my interest in pediatric leukemia research, which also allows for broadening the scope for cancer research in Arkansas. Dynamic collaborative efforts between the institutes are also supportive of the goal of the Winthrop P. Rockefeller Cancer Institute in achieving National Cancer Institute designation. I would like to contribute to the institutional goal and vision by publishing our innovative research, strengthening collaborative efforts and obtaining competitive research fundings. I am also highly motivated to host trainees at the undergraduate, graduate or advanced level in our laboratory and have them acquire critical assets, including knowledge, skills, and interest in cancer research.

Tell us about your current research?

Our laboratory presently focuses on a deadliest subtype of pediatric acute myeloid leukemia (AML). Although AML impacts all ages, AML with the ETO2-GLIS2 fusion oncoprotein is a unique entity of early childhood (< 3 years). Infants and young children with this type of AML have among the worst outcomes of all pediatric AML subtypes. The fusion between ETO2 and GLIS2 occurs due to an inversion event at chromosome16, which is not detected by routine cytogenetics and thus must be specifically sought by fluorescent in-situ hybridization technique or molecular studies, likely explaining its late and recent discovery. Whole genome sequencing studies have failed to identify additional second hit coding gene mutations in these cases and the overall mutational burden is among the lowest of all human cancers.

In contrast, laboratory stem-cell models show that introduction of the fusion alone is sufficient for malignant transformation. Thus, ETO2-GLIS2 AML is suspected to be critically supported by epigenetic mechanisms, however these have not been adequately investigated. Previous literature suggests that ETO2-GLIS2 induce havoc changes in chromatin architecture and preferentially activates H3K27ac marked chromatin at atypical (neo) gene loci, which are defined as super-enhancers (SE) that are supportive of sustenance of leukemic gene expression.

Based on previous literature and our preliminary data, we identified that mediator (MED) 12 like (MED12L) protein is epigenetically enhanced and overexpressed in ETO2-GLIS2 positive AML subgroup, and co-upregulated with CDK8 of the MED-kinase module. Given ETO2-GLIS2 and MED12L mutually occupies the neo-SE element, and MED proteins aid in formation and sustenance of SE activities in cancer, we aim to investigate the (1) MED12L interactions with ETO2-GLIS2 bound or unbound to SE associated proteins and determine (2) whether epigenetic perturbations of MED12L can impair aberrant transcriptional machinery and overall leukemic growth. Our studies are expected to develop novel insights into changes in chromatin architecture and mediator-enhancer mechanisms, favoring leukemic growth, which may be relevant to other AML subtypes and hematological malignancies.    

A native of Calcutta, India, Dr. Choudhury earned bachelor’s and master’s degrees from the University of Calcutta. He received a Ph.D. in biotechnology from the Indian Statistical Institute, during which time he received multiple senior research fellowship awards and a postdoctoral fellowship in nano science and technology.  In 2013, he was awarded a three-year postdoctoral fellowship from the W.M KECK Foundation at Purdue University to study in the laboratory of Professor Joseph Irudayaraj. He joined the UAMS Myeloma Center as a research associate in 2013 and was promoted to assistant professor in the Department of Pediatrics in 2020. He is a member of the Cancer Institute’s Cancer Biology Research Group. He received a 2020-2021 UAMS Seeds of Science Award. His work is widely published in such journals as Blood Cancer Journal, Cancers, Cancer Research Cells, Journal of Hematology & Oncology, Scientifics Reports, and Oncotarget.

Assistant Professor, Department of Pathology, UAMS College of Medicine; Cancer Biology Research Group, Winthrop P. Rockefeller Cancer Institute

What is your relationship to cancer?

Prior to joining the Winthrop P. Rockefeller Cancer Institute and UAMS, I worked at the National Institutes of Health (NIH) Clinical Center for 11 years. I had the unique experience to meet many cancer patients who joined our clinical trial programs. Experimental treatments provided by us were likely the last hope for them, and I admired their courage and generosity with all my heart. Because of this, I saw many patients fighting for their lives in the intensive care units, and most of them passed away soon after the experimental treatments failed. This experience completely changed my view of life and death. On the bright side, I witnessed firsthand the development of a breakthrough in cancer treatment called cancer immunotherapy. Several cancer patients were saved from certain death and are now cancer-free, in part because of my research at the NIH.

Tell us about your current research?

Cancer immunotherapy is a new type of cancer treatment and uses a patients’ own immune system to attack cancer. T-cells play a major role in cancer immunotherapy, and several types

of T cell-based cancer immunotherapy have shown strong clinical responses for cancer patients. However, most previous studies have been focused on therapies suitable for the Caucasian population. As a result, cancer patients within the underserved populations, including African American and Hispanic populations, are less likely to qualify for these new treatments

in the near future. To address this, I focus on the development of new T cell-based cancer immunotherapies for underserved populations. I feel very grateful that the Cancer

Institute and Translational Research Institute at UAMS support this type of research.

What do you hope to contribute to cancer research and to the Winthrop P. Rockefeller Cancer Institute?

As a team member at the Cancer Institute, I plan to establish a robust research program based

on my previous experience at the National Cancer Institute (NCI), NIH. Since I joined the UAMS, I appreciate the research environment, shared resources and funding provided by the Cancer Institute. I also feel grateful for the help and advice from my mentors through the mentorship program and KL2 program. More importantly, the leadership at the Cancer Institute, Department of Pathology and UAMS has led us to make significant progress in order to elevate the status of this institution. Therefore, I feel very proud to be part of this dream team, with the goal of becoming one of the NCI-designated cancer centers in the near future.

About Dr. Lu

Dr. Lu is a co-investigator with Mayumi Nakagawa, M.D., Ph.D., for an NCI R01 grant studying the T-cell responses to high-risk HPV. He is the recipient of the 2021 UAMS Translational Research Institute KL2 Award. A native of Taiwan, he received his Ph.D. training at Princess Margaret Cancer Centre, University of Toronto, Canada. After finishing his Ph.D. training, he became a postdoctoral visiting fellow at Surgery Branch, NCI, NIH. Lu was promoted to a staff scientist position, prior to joining the UAMS in early 2021. 

Fenghuang Zhan, M.D., is executive director of Myeloma Center Basic Research and the Morrison Family Endowed Chair at UAMS. He serves as a professor in the Department of Internal Medicine and is leader of the Genetics, Genomics and Proteomics faculty. His research is funded by competitive grants of over $3 million. He is a recipient of a $1.8 million grant from the Riney Foundation.

“The most important part of my contribution is to translate my research results into clinic usage to help improve myeloma care,” says Zhan.

View Research Profile

Tells about your current research

I’m researching drug resistance and immune therapy in multiple myeloma (MM). The extreme variability in survival among patients with MM suggests that specific genetic lesions, possibly reflected in altered gene expression profile patterns in tumor cells, may account for the divergent clinical outcomes. My laboratory is interested in understanding how the genetic alterations in cancer cells contribute to tumor progression, alter treatment response, and create vulnerabilities that may be targeted therapeutically. Our previous work demonstrates that High NEK2 drives myeloma drug resistance and poor prognosis. Monotherapy with PD-1/PD-L1 inhibitors has shown disappointing results in MM, even though targeting immune checkpoints represents a new and very promising approach for the treatment of many solid tumors and certain types of hematologic malignancies. Is there any relationship between NEK2 and the disappointing results of targeting immune checkpoints in MM? To facilitate our research, we are combining genetic and genomic tools that enable us to explore various aspects of cancer biology in a comprehensive way. Current efforts strive to identify new components of NEK2 networks and characterize their impact on immune checkpoints blockade response. In addition, we are defining new biomarkers for targeting immune checkpoint therapy and developing new strategies for high risk (PR/relapsed) MM patients. 

Another research focus is on tumor-initiating cells (TICs) in MM. Although a universally accepted TIC phenotype has not yet been identified, the establishment of a TIC phenotype is critical if we want to fully understand the biology of these cells. Many studies indicate that CD24 has been recognized as a legitimate cancer stem cell marker in multiple cancers. Our studies demonstrated that CD24⁺ MM cells maintain the features of self-renewal and drug resistance in MM, providing a biomarker for myeloma genesis and targeted therapy. Myeloma tumor-initiating cells (MM-TICs), characterized by increased drug resistance and self-renewal capacity, are very likely responsible for our failure to cure myeloma in the majority of patients. Our goal is (1) To determine how the CD24⁺ primary MM cells (CD38⁺CD45^–) contribute to drug resistance; (2) To define TIC features; and (3) To develop MM TIC-targeted therapies in vitro and in vivo in a pre-clinical mouse model.  

Multiple Myeloma is virtually always preceded by a monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM), which are pre-malignant conditions and more prevalent in the elderly population. MGUS patients are not routinely screened since there is currently no treatment that has demonstrated efficacy in reducing the risk of progression of MGUS to MM. Taking advantage of our expertise in MGUS and MM biology and the area of genomics, with relevant mouse models in hand and availability of exceptional human MGUS resources, we are uniquely positioned to discover the key factors that are associated with MGUS progression. Then we are able to develop novel therapies based on a modulation of MGUS risk factors. 

What is your relationship to cancer?

My paternal grandmother is a breast cancer survivor, and my paternal grandfather passed away from colorectal cancer when I was a child. They were both cigarette smokers like many others in their poor, rural and underserved community. Growing up, I saw how my grandparents and other family members struggle to quit smoking and suffer from tobacco-related diseases. These experiences compelled me to become an epidemiologist dedicated to improving smoking cessation and combatting tobacco-related heath disparities among populations disproportionately burdened by tobacco.

View Research Profile
dmjones2@uams.edu

What do you hope to contribute to the Cancer Institute? 

I hope to support the Winthrop P. Rockefeller Cancer Institute goal of achieving NCI designation by conducting and publishing innovative studies, developing community-based initiatives, and obtaining research funding. Tobacco use is a leading cause of cancer and cancer mortality, and smoking rates in Arkansas are higher than the national average. Through my research I seek to prevent and reduce tobacco use among Arkansans and inform tobacco control efforts at the national and state/local levels. I am excited to join the Cancer Institute as a public health professional and collaborate on cancer-related research to improve the health of Arkansans.

Tell us about your current research 

My current research focuses on the role of social-environmental and psychosocial factors as contributors to tobacco use and related disparities. My work often combines quantitative and qualitative epidemiologic methods. I aim to utilize my research to inform tobacco regulations and leverage technology-supported observational studies and interventions to increase successful smoking cessation among vulnerable and disadvantaged populations, such as African Americans and rural and low-income communities. 

I also completed predoctoral and postdoctoral fellowships with two NIDA/FDA funded Tobacco Centers of Regulatory Science (TCORS) and the Translational Addiction Research T32 program based in the UAMS Psychiatric Research Institute. My training informed my second line of research which focuses on tobacco regulatory science, a field of research specifically designed to inform real-time FDA regulation. My tobacco regulatory science studies aim to identify how risk perceptions and tobacco product characteristics (i.e., flavors, product type) influence tobacco use behaviors among disadvantaged populations.

I was recently awarded two pilot grants as PI, including one from the Arkansas Center for Health Disparities (ARCHD) in the UAMS College of Public Health. My mixed-methods pilot study investigates how perceived harmfulness of nicotine influences use of evidence-based and non-evidence based quit aids that contain nicotine (i.e., nicotine replacement therapy, e-cigarettes) among African American and White cigarette smokers aged 18-34. We aim to use findings from this study to inform future grant proposals and develop interventions to improve early age smoking cessation.

Associate Professor
Department of Biomedical Informatics
UAMS College of Medicine
Scientific Director, UAMS Genomics Facility

What is your relationship to cancer?

Growing up I was very close to my maternal grandfather, a retired New York City fireman and WWII veteran. He died from lung cancer when I was 15. He was a big person, 6’2” and 200 lbs. He was only 120 lbs. when he died.

I didn’t know how sick he was and that he was never going to get better. Every week, he seemed thinner and weaker, and I was often asking my mother why Papa was not getting better. I’ve kept his sons, also now retired New York City firefighters, informed of my lung cancer research.  We all still miss Papa.

What are your research goals? 

As a member of the Developmental Therapeutics Research Group, my research uses advanced molecular profiling to determine the role of the liquid biopsy in early stage cancer diagnosis. With the analysis of a simple blood test, we can find circulating tumor DNA (ctDNA), which are nucleic acid biomolecules shed by a tumor into the blood and detected by Next Generation Sequencing (NGS). Some of these tests are currently commercially available and FDA approved for patients with advanced (metastatic) disease. Now researchers are working to translate their foundational work into cutting-edge care for cancer patients at all stages of disease (and tumor types) and eventually for screening assays.

I began a clinical trial in 2019 to develop an advanced liquid biopsy method for diagnosing and monitoring lung cancer. Funded by a $1.47 million grant from the Food and Drug Administration (FDA), my lab tests lung tumor samples by running genetic sequencing and regrowing them using different methods. If the tumors are large enough, we test existing drugs and novel combinations of existing drugs on the tumors for the most effective treatment. This information is stored in a tumor bank so that doctors know the best treatment to use if the patient returns. We look for aggregate patterns on what treatments work best for different types of tumors.

In a related effort, I am part of an FDA-funded international collaboration whose recently published findings reveal that five commercially available assays can reliably detect circulating tumor DNA of late-stage and metastatic cancers.

Published April 12, 2021, in the journal Nature Biotechnology, the scientific study team includes researchers at the FDA’s National Center for Toxicological Research in Jefferson, Arkansas, and 12 participating laboratories in Europe, Australia, Asia and the United States.  Nature’s behind the paper channel  further explores aspects of how this research paper came to be and where subsequent research may lead.

What do you hope to contribute to cancer research and to the Cancer Institute?

As a medical oncologist, biomedical informaticist and computer engineer, I bring a unique combination of expertise that has served me well in the quest to make a simple blood test part of oncology clinical practice, along with advancing the personalized treatment of cancer.

As a cancer survivor, Dr. Wolfe brings a passion to pancreatic cancer research that few others can. A recent recipient of a TRI Career Development Award, Wolfe is investigating the role of oncogenic KRAS in regulating the DNA repair of RAD18, an enzyme with a major role in pancreatic cancer DNA repair. 

What is your relationship to cancer? How did you become involved in cancer research?

My journey to becoming an oncology physician and cancer researcher has been ongoing for nearly 20 years. After a personal bout with cancer in high school, I decided early on that I wanted to dedicate my career (and life) to helping cancer patients. I discovered that I was both passionate about laboratory research and clinical care, so I earned a dual M.D./Ph.D. My current research focus is on discovering novel therapeutic strategies for the deadly disease of pancreatic cancer. In the lab, I use genetic and proteomic approaches to address the fundamental mechanisms of genetic alterations in cancer cells which result in heightened DNA repair leading to radiation and chemotherapy resistance. I was recently awarded the UAMS Translational Research Institute’s KL2 Mentored Career Development Award to investigate the mechanism underlying the role of oncogenic KRAS in regulating the nuclear DNA repair enzyme RAD18, a major promoter of DNA repair in pancreatic cancer.

What do you hope to contribute to the UAMS Cancer Institute?

It is an honor to be joining the UAMS Cancer Institute as a physician-scientist in Radiation Oncology. I believe that I will contribute to the overall goals of the Cancer Institute which include development of novel treatment strategies for the deadly disease of pancreatic cancer, provide compassionate and excellent care for our cancer patients, and perform and publish translational cancer research and obtain research funding. All of these contributions will help propel UAMS to our goal of NCI designation.

More about Adam Wolfe, M.D., Ph.D.

I joined the Winthrop P. Rockefeller Cancer Institute in July 2021 after completing my residency in Radiation Oncology at Ohio State University (OSU). There, I completed a Holman Fellowship researching DNA repair mechanisms of resistance in pancreatic and thyroid cancers. I was awarded research funding from both the Radiation Oncology Institute and the Radiological Society of North America during my fellowship at OSU. I received dual M.D. and Ph.D. degrees from the Medical Scientist Training Program at The University of Texas McGovern Medical School and MD Anderson Cancer Center Graduate School of Biomedical Sciences in 2016.

View Dr. Wolfe’s page on the Cancer Institute Research Directory 

Neuro-oncologist specializing in brain and spine cancer

Dr. Horta earned her medical degree at the University of Sao Paulo in Brazil, where she also served a residency in neurology and completed a clinical fellowship in neuro-immunology. She completed a fellowship in research at the Neuro-immunology Laboratory at the Mayo Clinic in Rochester, MN, and a clinical fellowship in neuro-oncology at Henry Ford Hospital in Detroit. Horta also served a residency in neurology at the University of Minnesota in Minneapolis. She joined UAMS in 2020 as a neuro-oncologist and has since built UAMS’ neuro-oncology practice. 

Q. What is your relationship to cancer?

A. I think neuro-oncology chose me. Going back to my first residency, I took care of many more patients that were in the neurology ward because a tumor was causing their symptoms. In my second residency, the cases that caught my attention were neuro-oncology ones. Also, people close to me had brain tumors, and this gives me another perspective.  

Q. When did you first become involved in cancer research?

A. I first got involved in cancer research in 2011 at the Mayo Clinic when I was working with paraneoplastic diseases that cause neurological problems because of cancer in the patient’s body. In the attempt to fight cancer, the immune system sometimes gets confused and starts to attach to the brain, spinal cord or the nerves of the patient.

Q. What do you hope to contribute to the Cancer Institute at UAMS?

A. I hope to contribute so much to the UAMS Cancer Institute. When I came to UAMS, we had to first build the neuro-oncology service. We are now bringing pharmacological clinical trials to patients with brain tumors at UAMS. We are also trying to better understand the impact on cognition that many cancers bring to patients, and how we can develop ways to identify and follow it. A brain tumor diagnosis can impact the patient and family so much, causing depression and anxiety that not only bring worse quality of life, but also impacts survival.  This is another topic of study; how can we detect those mood disorders and how can we act upon it.

I am also seeing patients with neurofibromatosis and tuberous sclerosis. Those diseases can cause tumors and cancer in many parts of the body, but mainly the brain, spinal cord and nerves. We are trying to develop a Neurofibromatosis Multidisciplinary Clinic and bring clinical trials for those patients. Also, brain tumors in patients with tuberous sclerosis can be treated with an FDA-approved oral medication, and we are bringing this option to our patients.

Researchers at the UAMS Winthrop P. Rockefeller Cancer Institute are doing their part fight COVID-19.

Deputy Director Alan Tackett, Ph.D., and Josh Kennedy, M.D., associate professor in the UAMS College of Medicine Department of Pediatrics Division of Allergy and Immunology, are leading a National Institutes of Health (NIH)-funded team to track virus variants circulating in Arkansas.

The $770,000 NIH grant is devoted to a strategic collaboration among researchers, faculty and clinicians at UAMS, Arkansas Children’s, Baptist Health and the Arkansas Department of Health. The Arkansas Sequencing (ArkSeq) Consortium, as it’s referred to, will be a source for COVID-19 samples from across the state to be used for sequencing virus variants.

“NIH has strategically allocated funds in key sites across the nation for COVID variant identification and tracking,” Tackett said. “Our research team was identified as the group in Arkansas to lead these important efforts. With the surge in delta variant infections in our state, we have redirected resources from cancer and other disease research towards virus sequencing to help our state identify and track current and future variants of concern in the adult and pediatric populations,” he said.

“The delta variant is rampant across the U.S. and Arkansas,” said Kennedy. “It currently represents more than 80% of the genomes sequenced from samples from our state. We need to be ready for what variant might be next, and this work will help us identify these new variants when they develop,” he said.

To date, Arkansas has uploaded just over 1,700 COVID-19 samples to national databases –a total of only 0.48% of all cases.  Tackett and Kennedy expect to yield seven times more sequences from Arkansas for national databases and produce additional samples for future study. The ArkSeq Consortium has already provided more than 2,000 samples that will be sequenced through Kennedy’s lab and the genomics cores at Arkansas Children’s Research Institute (ACRI).

“Sequencing for variants of SARS-CoV-2 will help us to understand the evolution of the virus over time, and it will help determine when or if the virus can evade our immune systems and cause greater disease,” Kennedy said.  “We hope to provide this level of detail to front-line health care workers in our state to help more people faster.”

Kennedy is overseeing viral sequencing at an NIH Center of Biomedical Research Excellence, directed by Tackett at ACRI. Data analysis is conducted at UAMS under the direction of Stephanie Byrum, Ph.D., associate professor in the UAMS College of Medicine Department of Biochemistry and Molecular Biology and director of the Winthrop P. Rockefeller Cancer Institute Bioinformatics Shared Resource, and David Ussery, Ph.D., professor in the UAMS College of Medicine Department of Biomedical Informatics. Bioinformatics will be performed in collaboration with the Arkansas INBRE program at UAMS.

This research is supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number P20GM121293.